2-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2,3,4,5,6,7-hexahydro-1H-3-benzazonine

Base Information

Chemical Name:2-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2,3,4,5,6,7-hexahydro-1H-3-benzazonine
CAS No.:192133-92-9
Molecular Formula:C₃₅H₃₄N₂O₅
Molecular Weight:562.665
Hs Code.:

Synonyms:2-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2,3,4,5,6,7-hexahydro-1H-3-benzazonine

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Chemical Property of 2-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2,3,4,5,6,7-hexahydro-1H-3-benzazonine

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Technology Process of 2-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2,3,4,5,6,7-hexahydro-1H-3-benzazonine

There total 3 articles about 2-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2,3,4,5,6,7-hexahydro-1H-3-benzazonine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 494847-56-2
5-[(3-tert-Butoxycarbonyl-2,3,4,5,6,7-hexahydro-1H-benzo[d]azonine-2-carbonyl)-amino]-isophthalic acid dibenzyl ester

: 192133-92-9
2-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2,3,4,5,6,7-hexahydro-1H-3-benzazonine

Guidance literature:: With trifluoroacetic acid;
DOI:10.1016/S0960-894X(97)00211-4

Reference yield:

: 2,3,4,5,6,7-Hexahydro-1H-benzo[d]azonine-2-carboxylic acid; hydrochloride

: 192133-92-9
2-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2,3,4,5,6,7-hexahydro-1H-3-benzazonine

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / Et₃N / H₂O; dioxane / 48 h / 20 °C

2: diisopropylethylamine; bromotris(pyrrolidine)phosphonium hexafluorophosphate; DMAP / CH₂Cl₂ / 19 h / 20 °C

3: 187 mg / trifluoroacetic acid / 1 h / 20 °C

With dmap; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0223-5234(02)01351-X

Reference yield:

: 192133-88-3
N-(tert-butoxycarbonyl)-2,3,4,5,6,7-hexahydro-1H-3-benzazonine-2-carboxylic acid

: 192133-92-9
2-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-2,3,4,5,6,7-hexahydro-1H-3-benzazonine

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylethylamine; bromotris(pyrrolidine)phosphonium hexafluorophosphate; DMAP / CH₂Cl₂ / 19 h / 20 °C

2: 187 mg / trifluoroacetic acid / 1 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0223-5234(02)01351-X