(E)-ethyl 2-((E)-(4-(3,4-dicyanophenoxy)-3,5-dimethoxybenzylidene)hydrazono)-3,4-dimethyl-2,3-dihydrothiazole-5-carboxylate

Base Information

Chemical Name:(E)-ethyl 2-((E)-(4-(3,4-dicyanophenoxy)-3,5-dimethoxybenzylidene)hydrazono)-3,4-dimethyl-2,3-dihydrothiazole-5-carboxylate
CAS No.:1446892-05-2
Molecular Formula:C₂₅H₂₃N₅O₅S
Molecular Weight:505.554
Hs Code.:

Synonyms:(E)-ethyl 2-((E)-(4-(3,4-dicyanophenoxy)-3,5-dimethoxybenzylidene)hydrazono)-3,4-dimethyl-2,3-dihydrothiazole-5-carboxylate

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Chemical Property of (E)-ethyl 2-((E)-(4-(3,4-dicyanophenoxy)-3,5-dimethoxybenzylidene)hydrazono)-3,4-dimethyl-2,3-dihydrothiazole-5-carboxylate

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Technology Process of (E)-ethyl 2-((E)-(4-(3,4-dicyanophenoxy)-3,5-dimethoxybenzylidene)hydrazono)-3,4-dimethyl-2,3-dihydrothiazole-5-carboxylate

There total 3 articles about (E)-ethyl 2-((E)-(4-(3,4-dicyanophenoxy)-3,5-dimethoxybenzylidene)hydrazono)-3,4-dimethyl-2,3-dihydrothiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 31643-49-9
4-Nitrophthalonitrile

: 1446892-01-8
(E)-ethyl-2-((E)-(4-hydroxy-3,5-dimethoxy benzylidene)hydrazono)-3,4-dimethyl-2,3-dihydro-thiazole-5-carboxylate

: 1446892-05-2
(E)-ethyl 2-((E)-(4-(3,4-dicyanophenoxy)-3,5-dimethoxybenzylidene)hydrazono)-3,4-dimethyl-2,3-dihydrothiazole-5-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 120h; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.jorganchem.2013.04.043

Reference yield:

: 1446891-97-9
(E)-2-(4-hydroxy-3,5-dimethoxybenzylidene)-N-methylhydrazinecarbothioamide

: 1446892-05-2
(E)-ethyl 2-((E)-(4-(3,4-dicyanophenoxy)-3,5-dimethoxybenzylidene)hydrazono)-3,4-dimethyl-2,3-dihydrothiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 72 h / Inert atmosphere; Schlenk technique; Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 120 h / 60 °C / Inert atmosphere; Schlenk technique

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.jorganchem.2013.04.043

Reference yield:

: 134-96-3
syringic aldehyde

: 1446892-05-2
(E)-ethyl 2-((E)-(4-(3,4-dicyanophenoxy)-3,5-dimethoxybenzylidene)hydrazono)-3,4-dimethyl-2,3-dihydrothiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: neat (no solvent) / 4 h / 140 - 160 °C / Inert atmosphere; Schlenk technique

2: ethanol / 72 h / Inert atmosphere; Schlenk technique; Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 120 h / 60 °C / Inert atmosphere; Schlenk technique

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.jorganchem.2013.04.043