Technology Process of Toluene-4-sulfonic acid (2R,3R)-2-methyl-3-((3E,7E,11E)-3,7,11-trimethyl-13-phenylsulfanyl-trideca-3,7,11-trienyl)-oxiranylmethyl ester
There total 8 articles about Toluene-4-sulfonic acid (2R,3R)-2-methyl-3-((3E,7E,11E)-3,7,11-trimethyl-13-phenylsulfanyl-trideca-3,7,11-trienyl)-oxiranylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 28 percent / SeO2, tert-butyl-hydroperoxid (TBHP) / CH2Cl2; H2O / 18 h / 0 °C
2: 92 percent / tetrahydrofuran / 4 h / Ambient temperature
3: 95 percent / pyridin / 2 h
4: PBr3, pyridine / petroleum ether / 3 h / -17 °C
5: 45 percent / dimethylformamide / 16 h / 60 °C
6: 80 percent / K2CO3 / methanol / 3 h / Ambient temperature
7: 57 percent / tert-Butyl-hydroperoxid (TBHP), Molekularsieb 4 Angstroem, Ti(i-OPr)4, (-)-D-Diethyl-tartrat / CH2Cl2; toluene / 4 h / -40 - -20 °C
8: 81 percent / Pyridin / 16 h / 0 °C
With
pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; selenium(IV) oxide; Molekularsieb 4 Angstroem; phosphorus tribromide; potassium carbonate; (-)-diethyl tartrate;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; Petroleum ether;
DOI:10.1002/hlca.19900730721
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 92 percent / tetrahydrofuran / 4 h / Ambient temperature
2: 95 percent / pyridin / 2 h
3: PBr3, pyridine / petroleum ether / 3 h / -17 °C
4: 45 percent / dimethylformamide / 16 h / 60 °C
5: 80 percent / K2CO3 / methanol / 3 h / Ambient temperature
6: 57 percent / tert-Butyl-hydroperoxid (TBHP), Molekularsieb 4 Angstroem, Ti(i-OPr)4, (-)-D-Diethyl-tartrat / CH2Cl2; toluene / 4 h / -40 - -20 °C
7: 81 percent / Pyridin / 16 h / 0 °C
With
pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; Molekularsieb 4 Angstroem; phosphorus tribromide; potassium carbonate; (-)-diethyl tartrate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; Petroleum ether;
DOI:10.1002/hlca.19900730721
