1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Base Information

Chemical Name:1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile
CAS No.:1582270-97-0
Molecular Formula:C₁₈H₁₁F₄N₃O₂
Molecular Weight:377.298
Hs Code.:

Synonyms:1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

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Chemical Property of 1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

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Technology Process of 1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

There total 3 articles about 1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1582270-75-4
6-methyl-2-oxo-1-(prop-2-yn-1-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 458-02-6,154238-36-5
3-fluorobenzaldehyde oxime

: 1582270-97-0
1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: 6-methyl-2-oxo-1-(prop-2-yn-1-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; With sodium hypochlorite; triethylamine; In dichloromethane; water; at 0 ℃; for 1h;

3-fluorobenzaldehyde oxime; In dichloromethane; water; at 0 - 30 ℃; for 24h;
DOI:10.2174/1570178610666131118223356

Reference yield:

: 367-57-7
1,1,1-Trifluoro-2,4-pentanedione

: 1582270-97-0
1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine / ethanol / Reflux

2.1: potassium carbonate; sodium iodide / acetone / 20 °C

3.1: triethylamine; sodium hypochlorite / dichloromethane; water / 1 h / 0 °C

3.2: 24 h / 0 - 30 °C

With piperidine; sodium hypochlorite; potassium carbonate; triethylamine; sodium iodide; In ethanol; dichloromethane; water; acetone;
DOI:10.2174/1570178610666131118223356

Reference yield:

: 654-49-9
6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 1582270-97-0
1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; sodium iodide / acetone / 20 °C

2.1: triethylamine; sodium hypochlorite / dichloromethane; water / 1 h / 0 °C

2.2: 24 h / 0 - 30 °C

With sodium hypochlorite; potassium carbonate; triethylamine; sodium iodide; In dichloromethane; water; acetone;
DOI:10.2174/1570178610666131118223356