654-49-9

Usage

Uses

Used in Pharmaceutical Research:
6-METHYL-2-OXO-4-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIDINE-3-CARBONITRILE is used as a key intermediate in the synthesis of pharmaceuticals for its potential biological activities. It is particularly noted for its potential as a cardiovascular drug, contributing to the development of new treatments for heart-related conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 6-METHYL-2-OXO-4-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIDINE-3-CARBONITRILE is used as a versatile building block for creating more complex organic molecules. Its unique structure allows for the formation of various derivatives, expanding the scope of chemical reactions and molecule design.
Used as a Tyrosinase Inhibitor:
6-METHYL-2-OXO-4-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIDINE-3-CARBONITRILE is used as an inhibitor of tyrosinase, an enzyme that plays a crucial role in the production of melanin. By inhibiting this enzyme, the compound may have applications in treatments for pigmentation disorders or in the cosmetics industry for skin-lightening products.
Used in Controlled Laboratory Environments:
Due to its potential hazardous properties, 6-METHYL-2-OXO-4-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIDINE-3-CARBONITRILE is used exclusively by trained professionals within controlled laboratory settings. This ensures safety and proper handling during its application in research and development processes.

InChI:InChI=1/C8H5F3N2O/c1-4-2-6(8(9,10)11)5(3-12)7(14)13-4/h2H,1H3,(H,13,14)

Upstream product

• 110-89-4 piperidine 
• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 107-91-5 cyanoacetic acid amide 
• 109-77-3 malononitrile 

Downstream Products

• 1174047-24-5 C₁₆H₁₀F₄N₂O₂ 
• 651-77-4 2-hydroxy-6-methyl-5-nitro-4-(trifluoromethyl)nicotinonitrile 
• 24667-07-0 2-hydroxy-6-methyl-4-(trifluoromethyl)nicotinic acid 
• 1582270-89-0 1-((1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 1582270-90-3 1-((1-(3-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 1582270-91-4 6-methyl-2-oxo-4-(trifluoromethyl)-1-((1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)-1,2-dihydropyridine-3-carbonitrile 
• 1582270-92-5 1-((1-(4-chloro-3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 1582270-94-7 1-((1-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazol-4-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 1582270-97-0 1-((3-(3-fluorophenyl)isoxazol-5-yl)methyl)-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 1582270-98-1 6-methyl-1-((3-(4-nitrophenyl)isoxazol-5-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 451459-17-9 2-bromo-6-methyl-4-(trifluoromethyl)pyridine 
• 22123-19-9 6-methyl-4-(trifluoromethyl)pyridin-2(1H)-one 
• 13600-48-1 2-chloro-6-methyl-4-(trifluoromethyl)pyridine-3-carbonitrile 

Relevant academic research and scientific papers

A simple and facile method for the synthesis of novel 5/7 triflouromethyl-substituted 4(3H)-quinazolone regioisomers

The unsymmetrical 1,3-diketones 1 on reaction with malononitrile is resulted an interesting trifunctional intermediates 2 and 3. The intermediate 2 is hydrolyzed to give 2,6-dicarboxamido aniline 4 which on cyclisation gave two regioisomers of 1,2-dihydro-4(3H)-quinazolinones 5 and 6. The effect of substituents on compound 4 is characteristic for formation of regioisomers in different proportions. Each regioisomer on dehydrogenation under mild condition using active MnO2 gave corresponding 4(3H)-quinazolones 7 and 8, respectively.

5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection

Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.