(S)-tert-butyl (1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate
CAS No.:1425044-76-3
Molecular Formula:C₂₂H₂₃ClN₂O₃
Molecular Weight:398.889
Hs Code.:

Synonyms:(S)-tert-butyl (1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate

Suppliers and Price of (S)-tert-butyl (1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl (1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate

Chemical Property:

Purity/Quality:: 99%min ^*data from raw suppliers

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Technology Process of (S)-tert-butyl (1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate

There total 6 articles about (S)-tert-butyl (1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1350643-72-9
(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinoline-1(2H)-one

: 1425044-76-3
(S)-tert-butyl (1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₁₇H₁₅ClN₂O*ClH

: 1425044-76-3
(S)-tert-butyl (1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 21327-86-6
2-chloro-6-methylbenzoic acid

: 1425044-76-3
(S)-tert-butyl (1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C

1.2: 2 h / 25 - 40 °C / Cooling with ice

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -30 - -10 °C / Inert atmosphere

2.2: 2 h / -30 - -10 °C / Inert atmosphere

2.3: 10.5 h / 20 °C

3.1: diethylamine / N,N-dimethyl-formamide / 20 °C

With n-butyllithium; oxalyl dichloride; diethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;