5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<(phenylmethoxy)carbonyl>amino>propanoyl>amino>butanoate

Base Information

Chemical Name:5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<(phenylmethoxy)carbonyl>amino>propanoyl>amino>butanoate
CAS No.:134848-94-5
Molecular Formula:C₃₈H₅₃N₃O₁₀
Molecular Weight:711.853
Hs Code.:

5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<(phenylmethoxy)carbonyl>amino>propanoyl>amino>butanoate

Synonyms:5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<(phenylmethoxy)carbonyl>amino>propanoyl>amino>butanoate

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Chemical Property of 5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<(phenylmethoxy)carbonyl>amino>propanoyl>amino>butanoate

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Technology Process of 5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<(phenylmethoxy)carbonyl>amino>propanoyl>amino>butanoate

There total 5 articles about 5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<(phenylmethoxy)carbonyl>amino>propanoyl>amino>butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65710-57-8,81306-93-6
3-{[(benzyloxy)carbonyl]amino}-N-(tert-butoxycarbonyl)-L-alanine

: 5-((2R,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butyryloxy)-pentanoic acid benzyl ester

: 134848-94-5
5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<(phenylmethoxy)carbonyl>amino>propanoyl>amino>butanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; Yield given;
DOI:10.1021/jm00113a005

Reference yield:

: 542-28-9,26354-94-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 134848-94-5
5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<(phenylmethoxy)carbonyl>amino>propanoyl>amino>butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH / H₂O / 70 °C

2: Bu₄NBr / acetone / 24 h / Heating

3: 99 percent / 4-(dimethylamino)pyridine (DMAP), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC) / CH₂Cl₂ / 0 °C

4: TFA / CH₂Cl₂ / Ambient temperature

5: hydroxybenzotriazole monohydrate (HOBt), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (ECD) / CH₂Cl₂ / 0 - 20 °C

With dmap; sodium hydroxide; tetrabutylammomium bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; water; acetone;
DOI:10.1021/jm00113a005

Reference yield:

: 37435-69-1
5-hydroxypentanoic acid sodium salt

: 134848-94-5
5-oxo-5-(phenylmethoxy)pentyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<(phenylmethoxy)carbonyl>amino>propanoyl>amino>butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: Bu₄NBr / acetone / 24 h / Heating

2: 99 percent / 4-(dimethylamino)pyridine (DMAP), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC) / CH₂Cl₂ / 0 °C

3: TFA / CH₂Cl₂ / Ambient temperature

4: hydroxybenzotriazole monohydrate (HOBt), 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (ECD) / CH₂Cl₂ / 0 - 20 °C

With dmap; tetrabutylammomium bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; acetone;
DOI:10.1021/jm00113a005