37435-69-1

Basic information

• Product Name: 5-Hydroxypentanoic Acid SodiuM Salt
• Synonyms: 5-Hydroxypentanoic Acid SodiuM Salt;Sodium 5-hydroxypentanoate;Sodium 5-hydroxyvalerate;Sodium delta-hydroxyvalerate
• CAS NO: 37435-69-1
• Molecular Formula: C₅H₉O₃*Na
• Molecular Weight: 140.11293
• Mol File: 37435-69-1.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly)
• CAS DataBase Reference: 5-Hydroxypentanoic Acid SodiuM Salt(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hydroxypentanoic Acid SodiuM Salt(37435-69-1)
• EPA Substance Registry System: 5-Hydroxypentanoic Acid SodiuM Salt(37435-69-1)

Safety Data

• Hazardous Substances Data: 37435-69-1(Hazardous Substances Data)

Usage

Description

5-Hydroxypentanoic Acid Sodium Salt, with the chemical formula C5H9O3Na, is the sodium salt of 5-hydroxypentanoic acid, an organic compound and short-chain fatty acid. It is a white to off-white powder that is soluble in water, known for its slightly sweet taste and mild odor. This versatile compound is used across various industries due to its properties as a flavoring agent, pH adjuster, buffer, and chelating agent.

Uses

Used in the Food Industry:
5-Hydroxypentanoic Acid Sodium Salt is used as a flavoring agent for its slightly sweet taste, enhancing the flavor profiles of various food products.
Used in Pharmaceutical Applications:
5-Hydroxypentanoic Acid Sodium Salt is used as a pH adjuster and buffer to maintain the stability and effectiveness of pharmaceutical formulations.
Used in Cosmetic Applications:
5-Hydroxypentanoic Acid Sodium Salt is used as a pH adjuster and buffer in cosmetic products to ensure product stability and maintain the desired pH levels for optimal performance.
Used as a Chelating Agent:
5-Hydroxypentanoic Acid Sodium Salt is used as a chelating agent in various applications, including water treatment and industrial processes, to bind and remove metal ions, improving the efficiency and effectiveness of these processes.

Upstream product

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Downstream Products

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• 216770-60-4 1-O-benzyl-5-O-[1-(4-benzyloxycarbonylbutyl)]-phosphono-L-erythro-pent-2-ulose ethane-1,2-diyl dithioacetal 
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• 134848-96-7 benzyl 5-hydroxy pentanoate 

Relevant articles and documents

Mild and chemoselective lactone ring-opening with (TMS)ONa. Mechanistic studies and application to sweroside derivatives

Mild and chemoselective opening of lactones with sodium trimethylsilanolate in high yields and aprotic solvents is described. Kinetic studies demonstrate that the BAc2 mechanistic pathway is followed. Nucleophilic attack of silanolate onto the carbonyl of the lactone moiety is the rate-determining step. NaOH present as an impurity accelerates the reaction. The method was further applied to the base-sensitive and stable lactones derived from highly functionalized iridoid derivatives.

Modified oligonucleotides and compound that can be used for synthesizing same

The present disclosure falls within the field of biomedical technology, and in particular relates to modified oligonucleatides and a compound that can be used for synthesizing same and a method for modifying oligonucleotides. The present disclosure also relates to the use of the modified oligonucleotides for preventing and/or treating diseases associated with the liver in a subject.

Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents

A series of hybrid compounds based on the natural products artemisinin and thymoquinone was synthesized and investigated for their biological activity against the malaria parasite Plasmodium falciparum 3D7 strain, human cytomegalovirus (HCMV), and two leukemia cell lines (drug-sensitive CCRF-CEM and multidrug-resistant subline CEM/ADR5000). An unprecedented one-pot method of selective formation of C-10α-acetate 14 starting from a 1:1 mixture of C-10α- to C-10β-dihydroartemisinin was developed. The key step of this facile method is a mild decarboxylative activation of malonic acid mediated by DCC/DMAP. Ether-linked thymoquinone-artemisinin hybrids 6a/b stood out as the most active compounds in all categories, while showing no toxic side effects toward healthy human foreskin fibroblasts and thus being selective. They exhibited EC50 values of 0.2 μM against the doxorubicin-sensitive as well as the multidrug-resistant leukemia cells and therefore can be regarded as superior to doxorubicin. Moreover, they showed to be five times more active than the standard drug ganciclovir and nearly eight times more active than artesunic acid against HCMV. In addition, hybrids 6a/b possessed excellent antimalarial activity (EC50 = 5.9/3.7 nM), which was better than that of artesunic acid (EC50 = 8.2 nM) and chloroquine (EC50 = 9.8 nM). Overall, most of the presented thymoquinone-artemisinin-based hybrids exhibit an excellent and broad variety of biological activities (anticancer, antimalarial, and antiviral) combined with a low toxicity/high selectivity profile.