3-{[(furan-2-ylmethyl)-amino]-methyl}-3-methyl-cyclohex-1-enecarbonitrile

Base Information

Chemical Name:3-{[(furan-2-ylmethyl)-amino]-methyl}-3-methyl-cyclohex-1-enecarbonitrile
CAS No.:862563-48-2
Molecular Formula:C₁₄H₁₈N₂O
Molecular Weight:230.31
Hs Code.:

Synonyms:3-{[(furan-2-ylmethyl)-amino]-methyl}-3-methyl-cyclohex-1-enecarbonitrile

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Chemical Property of 3-{[(furan-2-ylmethyl)-amino]-methyl}-3-methyl-cyclohex-1-enecarbonitrile

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Technology Process of 3-{[(furan-2-ylmethyl)-amino]-methyl}-3-methyl-cyclohex-1-enecarbonitrile

There total 6 articles about 3-{[(furan-2-ylmethyl)-amino]-methyl}-3-methyl-cyclohex-1-enecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 862563-47-1
trifluoromethanesulfonic acid 3-{[(furan-2-ylmethyl)-amino]-methyl}-3-methyl-cyclohex-1-enyl ester

: potassium cyanide

: 862563-48-2
3-{[(furan-2-ylmethyl)-amino]-methyl}-3-methyl-cyclohex-1-enecarbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether; In benzene; at 75 ℃; for 39h;
DOI:10.1002/chem.200701290

Reference yield:

: 862563-47-1
trifluoromethanesulfonic acid 3-{[(furan-2-ylmethyl)-amino]-methyl}-3-methyl-cyclohex-1-enyl ester

: 151-50-8
potassium cyanide

: 862563-48-2
3-{[(furan-2-ylmethyl)-amino]-methyl}-3-methyl-cyclohex-1-enecarbonitrile

Guidance literature:: With 18-crown-6 ether; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In benzene; at 25 ℃; for 39h;
DOI:10.1021/ol051184v

Reference yield:

: 862563-59-5
trifluoromethanesulfonic acid 3-formyl-3-methyl-cyclohex-1-enyl ester

: 862563-48-2
3-{[(furan-2-ylmethyl)-amino]-methyl}-3-methyl-cyclohex-1-enecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; molecular sieves 3 Angstroem / methanol / 17 h / 23 °C

2: NaBH₄ / methanol / 0.5 h

3: 0.49 g / 18-crown-6 / Pd(PPh₃)4 / benzene / 39 h / 25 °C

With sodium tetrahydroborate; 18-crown-6 ether; 3 A molecular sieve; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; benzene;
DOI:10.1021/ol051184v