[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2-chloroanhlino)methyl]benzoate

Base Information

Chemical Name:[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2-chloroanhlino)methyl]benzoate
CAS No.:1612896-69-1
Molecular Formula:C₂₉H₂₅Cl₃N₂O₅
Molecular Weight:587.887
Hs Code.:

Synonyms:[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2-chloroanhlino)methyl]benzoate

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Chemical Property of [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2-chloroanhlino)methyl]benzoate

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Technology Process of [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2-chloroanhlino)methyl]benzoate

There total 8 articles about [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2-chloroanhlino)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1611454-85-3
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-formylbenzoate

: 95-51-2
o-chloroaniline

: 1612896-69-1
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2-chloroanhlino)methyl]benzoate

Guidance literature:: [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-formylbenzoate; o-chloroaniline; With acetic acid; In dichloromethane; at 20 ℃; for 24h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 100868-46-0
3,5-dichloro-4-picoline

: 1612896-69-1
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2-chloroanhlino)methyl]benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: methanol; chloroform / 2 h / 20 °C / Resolution of racemate

4.1: potassium tert-butylate / methanol / 24 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 21 h / 20 °C

7.1: acetic acid / dichloromethane / 24 h / 20 °C

7.2: 24 h / 20 °C

With dmap; potassium tert-butylate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1416002-35-1
(R,S)-(2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethyl)(R)-2-(6-methoxynaphthalen-2-yl)propanoate

: 1612896-69-1
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 3-[(2-chloroanhlino)methyl]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol; chloroform / 2 h / 20 °C / Resolution of racemate

2.1: potassium tert-butylate / methanol / 24 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 21 h / 20 °C

5.1: acetic acid / dichloromethane / 24 h / 20 °C

5.2: 24 h / 20 °C

With dmap; potassium tert-butylate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;