Pyrrolidine, 1-(bromoacetyl)-2,5-dimethyl-, (2S-trans)- (9CI)

Base Information

• Chemical Name: Pyrrolidine, 1-(bromoacetyl)-2,5-dimethyl-, (2S-trans)- (9CI)
• CAS No.: 123265-82-7
• Molecular Formula: C8H14 Br N O
• Molecular Weight: 220.10686
• Mol file: 123265-82-7.mol

Synonyms:Pyrrolidine, 1-(bromoacetyl)-2,5-dimethyl-, (2S-trans)- (9CI)

Chemical Property of Pyrrolidine, 1-(bromoacetyl)-2,5-dimethyl-, (2S-trans)- (9CI)

Chemical Property:

• PSA: 20.31000
• LogP: 1.71860

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolidine, 1-(bromoacetyl)-2,5-dimethyl-, (2S-trans)- (9CI)

There total 1 articles about Pyrrolidine, 1-(bromoacetyl)-2,5-dimethyl-, (2S-trans)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(2S,5S)-2,5-dimethylpyrrolidine (117968-50-0) + 2-Bromoacetyl bromide (598-21-0) → 2-Bromo-1-((2S,5S)-2,5-dimethyl-pyrrolidin-1-yl)-ethanone (123265-82-7,123265-83-8,157905-03-8)

Guidance literature:

With sodium carbonate; In dichloromethane; at -40 ℃; for 10h;

DOI:10.1002/hlca.19940770322

Reference yield: 91.0%

2-Bromo-1-((2S,5S)-2,5-dimethyl-pyrrolidin-1-yl)-ethanone (123265-82-7,123265-83-8,157905-03-8) + N-(3-hydroxy-3-phenylpropyl)-4-methyl-benzenesulfonamide (158867-57-3) → (2S,5S)-1--2,5-dimethylpyrrolidine

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1002/hlca.19940770322

Reference yield:

2-Bromo-1-((2S,5S)-2,5-dimethyl-pyrrolidin-1-yl)-ethanone (123265-82-7,123265-83-8,157905-03-8) → (2S,5S)-1--2,5-dimethylpyrrolidine (158867-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / K(t-BuO) / dimethylformamide / 50 °C

2: 75 percent / pyridinium dichromate / CH₂Cl₂

With dipyridinium dichromate; potassium tert-butylate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19940770322

upstream raw materials:

(2S,5S)-2,5-dimethylpyrrolidine

2-Bromoacetyl bromide

Downstream raw materials:

(2S,5S)-1--2,5-dimethylpyrrolidine