benzyl (S)-2-(5-(dimethylamino)naphthalene-1-sulfonamidyl)-3-hydroxypropionate

Base Information

Chemical Name:benzyl (S)-2-(5-(dimethylamino)naphthalene-1-sulfonamidyl)-3-hydroxypropionate
CAS No.:246048-04-4
Molecular Formula:C₂₂H₂₄N₂O₅S
Molecular Weight:428.509
Hs Code.:

Synonyms:benzyl (S)-2-(5-(dimethylamino)naphthalene-1-sulfonamidyl)-3-hydroxypropionate

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Chemical Property of benzyl (S)-2-(5-(dimethylamino)naphthalene-1-sulfonamidyl)-3-hydroxypropionate

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Technology Process of benzyl (S)-2-(5-(dimethylamino)naphthalene-1-sulfonamidyl)-3-hydroxypropionate

There total 1 articles about benzyl (S)-2-(5-(dimethylamino)naphthalene-1-sulfonamidyl)-3-hydroxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 605-65-2
5-(dimethylamino)naphth-1-ylsulfonyl chloride

: 60022-62-0,879278-55-4,151651-44-4
L-serine benzyl ester hydrochloride

: 246048-04-4
benzyl (S)-2-(5-(dimethylamino)naphthalene-1-sulfonamidyl)-3-hydroxypropionate

Guidance literature:: With sodium hydrogencarbonate; In water; acetone; for 14h;
DOI:10.1021/jo982477n

Reference yield: 70.0%

: 70845-73-7
3,4-bis(benzyloxy)-5-methoxybenzoic acid

: 246048-04-4
benzyl (S)-2-(5-(dimethylamino)naphthalene-1-sulfonamidyl)-3-hydroxypropionate

: 246048-05-5
benzyl (S)-2-(5-(dimethylamino)naphthalene-1-sulfonamidyl)-3-((3,4-bis(benzyloxy)-5-methoxybenzoyl)oxy)propionate

Guidance literature:: With dmap; dacarbazine; In dichloromethane; at 20 ℃;
DOI:10.1021/jo982477n

Reference yield:

: 246048-04-4
benzyl (S)-2-(5-(dimethylamino)naphthalene-1-sulfonamidyl)-3-hydroxypropionate

: 246047-89-2
5-Methoxy-3,4-dioxo-cyclohexa-1,5-dienecarboxylic acid (S)-2-carboxy-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / DMAP; DIC / CH₂Cl₂ / 20 °C

2: 98 percent / H₂ / Pd/C / tetrahydrofuran / 14 h / 20 °C / 760 Torr

3: 44 percent / orthochloranil / tetrahydrofuran; diethyl ether / 12.5 h / -42 - -20 °C

With dmap; o-tetrachloroquinone; hydrogen; dacarbazine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Esterification / 2: Catalytic hydrogenation / 3: Oxidation;
DOI:10.1021/jo982477n