4-Acetylamino-5-amino-2-chloro-benzoic acid methyl ester

Base Information

• Chemical Name: 4-Acetylamino-5-amino-2-chloro-benzoic acid methyl ester
• CAS No.: 126436-18-8
• Molecular Formula: C₁₀H₁₁ClN₂O₃
• Molecular Weight: 242.662
• Mol file: 126436-18-8.mol

Synonyms:4-Acetylamino-5-amino-2-chloro-benzoic acid methyl ester

Chemical Property of 4-Acetylamino-5-amino-2-chloro-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-Acetylamino-5-amino-2-chloro-benzoic acid methyl ester

There total 1 articles about 4-Acetylamino-5-amino-2-chloro-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-(acetylamino)-2-chloro-5-nitrobenzoate (106125-46-6) → 4-Acetylamino-5-amino-2-chloro-benzoic acid methyl ester (126436-18-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 4h; under 760 Torr; Ambient temperature;

DOI:10.1248/cpb.42.560

Reference yield:

4-Acetylamino-5-amino-2-chloro-benzoic acid methyl ester (126436-18-8) → (6-Chloro-2-methyl-1H-benzoimidazol-5-yl)-methanol (126436-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 6N aq. HCl / acetic acid / 2 h / Heating

2: LiAlH₄ / tetrahydrofuran / 2 h / -30 °C

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; acetic acid;

DOI:10.1248/cpb.42.560

Reference yield:

4-Acetylamino-5-amino-2-chloro-benzoic acid methyl ester (126436-18-8) → 6-chloro-5-formyl-2-methyl-benzimidazole (126436-27-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 6N aq. HCl / acetic acid / 2 h / Heating

2: LiAlH₄ / tetrahydrofuran / 2 h / -30 °C

3: 57.6 percent / MnO₂ / ethyl acetate / 6 h / Heating

With hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; acetic acid; ethyl acetate;

DOI:10.1248/cpb.42.560

upstream raw materials:

methyl 4-(acetylamino)-2-chloro-5-nitrobenzoate

Downstream raw materials:

(6-Chloro-2-methyl-1H-benzoimidazol-5-yl)-methanol

6-chloro-5-formyl-2-methyl-benzimidazole

Refernces