1H-Benzimidazole-5-methanol,6-chloro-2-methyl-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole-5-methanol,6-chloro-2-methyl-(9CI)
• CAS No.: 126436-23-5
• Molecular Formula: C₉H₉ClN₂O
• Molecular Weight: 196.636
• Mol file: 126436-23-5.mol

Synonyms:1H-Benzimidazole-5-methanol,6-chloro-2-methyl-(9CI)

Chemical Property of 1H-Benzimidazole-5-methanol,6-chloro-2-methyl-(9CI)

Chemical Property:

• Boiling Point: 467.4±30.0 °C(Predicted)
• PKA: 10.46±0.10(Predicted)
• PSA: 48.91000
• Density: 1.433±0.06 g/cm3(Predicted)
• LogP: 2.01700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole-5-methanol,6-chloro-2-methyl-(9CI)

There total 3 articles about 1H-Benzimidazole-5-methanol,6-chloro-2-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloro-5-methoxycarbonyl-2-methylbenzimidazole (126436-19-9) → (6-Chloro-2-methyl-1H-benzoimidazol-5-yl)-methanol (126436-23-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -30 ℃; for 2h;

DOI:10.1248/cpb.42.560

Reference yield:

methyl 4-(acetylamino)-2-chloro-5-nitrobenzoate (106125-46-6) → (6-Chloro-2-methyl-1H-benzoimidazol-5-yl)-methanol (126436-23-5)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 4 h / 760 Torr / Ambient temperature

2: 6N aq. HCl / acetic acid / 2 h / Heating

3: LiAlH₄ / tetrahydrofuran / 2 h / -30 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;

DOI:10.1248/cpb.42.560

Reference yield:

4-Acetylamino-5-amino-2-chloro-benzoic acid methyl ester (126436-18-8) → (6-Chloro-2-methyl-1H-benzoimidazol-5-yl)-methanol (126436-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 6N aq. HCl / acetic acid / 2 h / Heating

2: LiAlH₄ / tetrahydrofuran / 2 h / -30 °C

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; acetic acid;

DOI:10.1248/cpb.42.560

upstream raw materials:

6-chloro-5-methoxycarbonyl-2-methylbenzimidazole

4-Acetylamino-5-amino-2-chloro-benzoic acid methyl ester

methyl 4-(acetylamino)-2-chloro-5-nitrobenzoate

Downstream raw materials:

6-chloro-5-formyl-2-methyl-benzimidazole

Refernces