2,5-dioxopyrrolidin-1-yl 4-{[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl}piperazine-1-carboxylate

Base Information

Chemical Name:2,5-dioxopyrrolidin-1-yl 4-{[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl}piperazine-1-carboxylate
CAS No.:1460030-26-5
Molecular Formula:C₂₁H₂₅F₃N₄O₅
Molecular Weight:470.449
Hs Code.:

Synonyms:2,5-dioxopyrrolidin-1-yl 4-{[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl}piperazine-1-carboxylate

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Chemical Property of 2,5-dioxopyrrolidin-1-yl 4-{[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl}piperazine-1-carboxylate

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Technology Process of 2,5-dioxopyrrolidin-1-yl 4-{[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl}piperazine-1-carboxylate

There total 3 articles about 2,5-dioxopyrrolidin-1-yl 4-{[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl}piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 74124-79-1
di(succinimido) carbonate

: 1446819-03-9
4-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]morpholine

: 1460030-26-5
2,5-dioxopyrrolidin-1-yl 4-{[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl}piperazine-1-carboxylate

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃;

Reference yield:

: 736990-96-8
4-(morpholin-4-yl)-2-(trifluoromethyl)benzaldehyde

: 1460030-26-5
2,5-dioxopyrrolidin-1-yl 4-{[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl}piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,2-dichloro-ethane / 0.5 h / 20 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3.1: triethylamine / acetonitrile / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 90176-80-0
2-(trifluoromethyl)-4-fluorobenzaldehyde

: 1460030-26-5
2,5-dioxopyrrolidin-1-yl 4-{[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl}piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 100 °C

2.1: 1,2-dichloro-ethane / 0.5 h / 20 °C

2.2: 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4.1: triethylamine / acetonitrile / 20 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; acetonitrile;