(1R,2R,3S)-3-amino-1-(tert-butyldimethylsilyloxy)-1-methylcyclohexan-2-ol

Base Information

Chemical Name:(1R,2R,3S)-3-amino-1-(tert-butyldimethylsilyloxy)-1-methylcyclohexan-2-ol
CAS No.:1259279-92-9
Molecular Formula:C₁₃H₂₉NO₂Si
Molecular Weight:259.464
Hs Code.:

Synonyms:(1R,2R,3S)-3-amino-1-(tert-butyldimethylsilyloxy)-1-methylcyclohexan-2-ol

Suppliers and Price of (1R,2R,3S)-3-amino-1-(tert-butyldimethylsilyloxy)-1-methylcyclohexan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,3S)-3-amino-1-(tert-butyldimethylsilyloxy)-1-methylcyclohexan-2-ol

Chemical Property:

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Technology Process of (1R,2R,3S)-3-amino-1-(tert-butyldimethylsilyloxy)-1-methylcyclohexan-2-ol

There total 7 articles about (1R,2R,3S)-3-amino-1-(tert-butyldimethylsilyloxy)-1-methylcyclohexan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,2R,3S)-3-azido-1-(tert-butyldimethylsilyloxy)-1-methylcyclo-hexan-2-ol

: 1259279-92-9
(1R,2R,3S)-3-amino-1-(tert-butyldimethylsilyloxy)-1-methylcyclohexan-2-ol

Guidance literature:: With palladium on carbon; hydrogen; In ethyl acetate; under 760.051 Torr;

Reference yield:

: (1R,2R,3S)-3-azido-1-(tert-butyldimethylsilyloxy)-1-methylcyclo-hexan-2-ol

: 7440-05-3
palladium

: 1259279-92-9
(1R,2R,3S)-3-amino-1-(tert-butyldimethylsilyloxy)-1-methylcyclohexan-2-ol

Guidance literature:: In ethyl acetate;

Reference yield:

: 88494-89-7
(R)-(+)-1-methyl-2-cyclohexen-1-ol

: 1259279-92-9
(1R,2R,3S)-3-amino-1-(tert-butyldimethylsilyloxy)-1-methylcyclohexan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-2,2,4-triazole; dmap / N,N-dimethyl-formamide / 20 °C

2: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 20 h / 20 °C / Inert atmosphere

3: sodium azide; ammonium chloride / water; methanol / 12 h / 60 °C

4: hydrogen; palladium on carbon / ethyl acetate / 760.05 Torr

With dmap; sodium azide; palladium on carbon; hydrogen; sodium hydrogencarbonate; ammonium chloride; 1H-2,2,4-triazole; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;