N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride

Base Information

• Chemical Name: N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride
• CAS No.: 1264737-64-5
• Molecular Formula: C₁₂H₁₆FNO₃S
• Molecular Weight: 273.328
• Mol file: 1264737-64-5.mol

Synonyms:N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride

Chemical Property of N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride

There total 7 articles about N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

sodium (tert-butoxycarbonyl)(p-tolylsulfinyl)amide → N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride (1264737-64-5)

Guidance literature:

With Selectfluor; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.202002265

Reference yield:

C12H16ClNO3S → N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride (1264737-64-5)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In acetonitrile; at 21 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol103030w

Reference yield:

tert-butyl (4-tolylsulfinyl)-carbamate (1050609-74-9) → N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride (1264737-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tert-butylhypochlorite / dichloromethane / 2 h / 0 °C / Inert atmosphere

2: potassium fluoride; 18-crown-6 ether / acetonitrile / 16 h / 21 °C / Inert atmosphere

With potassium fluoride; 18-crown-6 ether; tert-butylhypochlorite; In dichloromethane; acetonitrile;

DOI:10.1021/ol103030w

upstream raw materials:

tert-butyl (4-tolylsulfinyl)-carbamate

para-thiocresol

Downstream raw materials:

N-(tert-butylcarbamoyl)-4-Methylbenzene-trifluoromethyl sulfoximine