N-(tert-butylcarbamoyl)-4-Methylbenzene-trifluoromethyl sulfoximine

Base Information

• Chemical Name: N-(tert-butylcarbamoyl)-4-Methylbenzene-trifluoromethyl sulfoximine
• CAS No.: 1264737-76-9
• Molecular Formula: C₁₃H₁₆F₃NO₃S
• Molecular Weight: 323.336
• Mol file: 1264737-76-9.mol

Synonyms:N-(tert-butylcarbamoyl)-4-Methylbenzene-trifluoromethyl sulfoximine

Chemical Property of N-(tert-butylcarbamoyl)-4-Methylbenzene-trifluoromethyl sulfoximine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butylcarbamoyl)-4-Methylbenzene-trifluoromethyl sulfoximine

There total 3 articles about N-(tert-butylcarbamoyl)-4-Methylbenzene-trifluoromethyl sulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride (1264737-64-5) + (trifluoromethyl)trimethylsilane (81290-20-2) → N-(tert-butylcarbamoyl)-4-Methylbenzene-trifluoromethyl sulfoximine (1264737-76-9)

Guidance literature:

N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride; (trifluoromethyl)trimethylsilane; In tetrahydrofuran; at 21 ℃; for 0.166667h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 21 ℃; for 12.5h; Inert atmosphere;

DOI:10.1021/ol103030w

Reference yield:

tert-butyl (4-tolylsulfinyl)-carbamate (1050609-74-9) → N-(tert-butylcarbamoyl)-4-Methylbenzene-trifluoromethyl sulfoximine (1264737-76-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tert-butylhypochlorite / dichloromethane / 2 h / 0 °C / Inert atmosphere

2.1: potassium fluoride; 18-crown-6 ether / acetonitrile / 16 h / 21 °C / Inert atmosphere

3.1: tetrahydrofuran / 0.17 h / 21 °C / Inert atmosphere

3.2: 12.5 h / 21 °C / Inert atmosphere

With potassium fluoride; 18-crown-6 ether; tert-butylhypochlorite; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/ol103030w

Reference yield:

C12H16ClNO3S → N-(tert-butylcarbamoyl)-4-Methylbenzene-trifluoromethyl sulfoximine (1264737-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium fluoride; 18-crown-6 ether / acetonitrile / 16 h / 21 °C / Inert atmosphere

2.1: tetrahydrofuran / 0.17 h / 21 °C / Inert atmosphere

2.2: 12.5 h / 21 °C / Inert atmosphere

With potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ol103030w

upstream raw materials:

tert-butyl (4-tolylsulfinyl)-carbamate

N-(tert-butyl carbamoyl)-4-Methylbenzene sulfonimidoyl fluoride

(trifluoromethyl)trimethylsilane