thiotolyl 3-O-acetyl-4-O-benzyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-2-(trichloroethylcarbonylamino)-β-D-glucopyranoside

Base Information

Chemical Name:thiotolyl 3-O-acetyl-4-O-benzyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-2-(trichloroethylcarbonylamino)-β-D-glucopyranoside
CAS No.:1386972-53-7
Molecular Formula:C₄₁H₄₆Cl₃NO₇SSi
Molecular Weight:831.329
Hs Code.:

Synonyms:thiotolyl 3-O-acetyl-4-O-benzyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-2-(trichloroethylcarbonylamino)-β-D-glucopyranoside

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Chemical Property of thiotolyl 3-O-acetyl-4-O-benzyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-2-(trichloroethylcarbonylamino)-β-D-glucopyranoside

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Technology Process of thiotolyl 3-O-acetyl-4-O-benzyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-2-(trichloroethylcarbonylamino)-β-D-glucopyranoside

There total 12 articles about thiotolyl 3-O-acetyl-4-O-benzyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-2-(trichloroethylcarbonylamino)-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1386972-44-6
C₂₂H₂₅N₃O₅S

: 1386972-53-7
thiotolyl 3-O-acetyl-4-O-benzyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-2-(trichloroethylcarbonylamino)-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: sodium methylate / methanol / 3 h / 20 °C

2.2: Dowex 50X-W-H⁺ ion-exchange resin

3.1: tributylphosphine / dichloromethane; water / 27 h / 20 °C

4.1: pyridine / 10 h / 20 °C

5.1: pyridine / 10 h / 20 °C

With pyridine; 1H-imidazole; tributylphosphine; sodium methylate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1080/07328303.2012.658274

Reference yield:

: thiotolyl 3-O-acetyl-2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside

: 1386972-53-7
thiotolyl 3-O-acetyl-4-O-benzyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-2-(trichloroethylcarbonylamino)-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,6-dimethylpyridine; di-n-butylboryl trifluoromethanesulfonate; diborane / tetrahydrofuran / 10 h / 0 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C

3.1: sodium methylate / methanol / 3 h / 20 °C

3.2: Dowex 50X-W-H⁺ ion-exchange resin

4.1: tributylphosphine / dichloromethane; water / 27 h / 20 °C

5.1: pyridine / 10 h / 20 °C

6.1: pyridine / 10 h / 20 °C

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; tributylphosphine; di-n-butylboryl trifluoromethanesulfonate; sodium methylate; diborane; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1080/07328303.2012.658274

Reference yield:

: C₃₆H₄₁N₃O₄SSi

: 1386972-53-7
thiotolyl 3-O-acetyl-4-O-benzyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-2-(trichloroethylcarbonylamino)-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1: tributylphosphine / dichloromethane; water / 27 h / 20 °C

2: pyridine / 10 h / 20 °C

3: pyridine / 10 h / 20 °C

With pyridine; tributylphosphine; In dichloromethane; water;
DOI:10.1080/07328303.2012.658274