(S)-1-(4-(benzyloxy)-3-((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: (S)-1-(4-(benzyloxy)-3-((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1438250-78-2
• Molecular Formula: C₄₅H₅₀N₂O₆
• Molecular Weight: 714.902
• Mol file: 1438250-78-2.mol

Synonyms:(S)-1-(4-(benzyloxy)-3-((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property of (S)-1-(4-(benzyloxy)-3-((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(4-(benzyloxy)-3-((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 7 articles about (S)-1-(4-(benzyloxy)-3-((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

(S)-1-(4-(benzyloxy)-3-bromobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (3804-06-6) + (R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol (19879-50-6) → (S)-1-(4-(benzyloxy)-3-((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (1438250-78-2)

Guidance literature:

With pyridine; copper(I) bromide dimethylsulfide complex; caesium carbonate; for 20h; Reflux;

DOI:10.1248/cpb.c12-00820

Reference yield:

(1R)-7-(benzyloxy)-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydroisoquinoline (1438250-58-8) → (S)-1-(4-(benzyloxy)-3-((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (1438250-78-2)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid; hydrazine hydrate / ethanol / 2 h / Reflux

2: sodium tetrahydroborate / methanol; water / 0 - 20 °C

3: palladium 10% on activated carbon; acetic acid; hydrogen / methanol / 7 h / 20 °C

4: pyridine; copper(I) bromide dimethylsulfide complex; caesium carbonate / 20 h / Reflux

With pyridine; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; palladium 10% on activated carbon; hydrogen; caesium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; In methanol; ethanol; water; 4: |Ullmann Condensation;

DOI:10.1248/cpb.c12-00820

Reference yield:

C25H27NO3 → (S)-1-(4-(benzyloxy)-3-((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (1438250-78-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol; water / 0 - 20 °C

2: palladium 10% on activated carbon; acetic acid; hydrogen / methanol / 7 h / 20 °C

3: pyridine; copper(I) bromide dimethylsulfide complex; caesium carbonate / 20 h / Reflux

With pyridine; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; In methanol; water; 3: |Ullmann Condensation;

DOI:10.1248/cpb.c12-00820

upstream raw materials:

(1R)-7-(benzyloxy)-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydroisoquinoline

(R)-7-(benzyloxy)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

(S)-1-(4-(benzyloxy)-3-bromobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

(R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol

Downstream raw materials:

1'-epi-neferine