2-(5-chloro-2-{[4-chloro-2-fluorophenylmethyl]oxy}phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(5-chloro-2-{[4-chloro-2-fluorophenylmethyl]oxy}phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 892664-20-9
• Molecular Formula: C₁₉H₂₀BCl₂FO₃
• Molecular Weight: 397.081
• Mol file: 892664-20-9.mol

Synonyms:2-(5-chloro-2-{[4-chloro-2-fluorophenylmethyl]oxy}phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 2-(5-chloro-2-{[4-chloro-2-fluorophenylmethyl]oxy}phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

• Boiling Point: 484.2±45.0 °C(Predicted)
• Density: 1.26±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(5-chloro-2-{[4-chloro-2-fluorophenylmethyl]oxy}phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 7 articles about 2-(5-chloro-2-{[4-chloro-2-fluorophenylmethyl]oxy}phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

4-chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene (892664-11-8) + 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) + isopropylmagnesium chloride (1068-55-9) → 2-(5-chloro-2-{[4-chloro-2-fluorophenylmethyl]oxy}phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (892664-20-9) + C26H17BCl4F2O3

Guidance literature:

4-chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene; isopropylmagnesium chloride; In toluene; at -10 - -3 ℃;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In toluene; at 0 - 20 ℃;

DOI:10.1021/op800169s

Reference yield:

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) → 2-(5-chloro-2-{[4-chloro-2-fluorophenylmethyl]oxy}phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (892664-20-9)

Guidance literature:

4-chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; at -10 ℃; for 0.5h;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at -10 - 20 ℃; for 18h; Product distribution / selectivity;

Reference yield:

2-isopropyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (76347-13-2) → 2-(5-chloro-2-{[4-chloro-2-fluorophenylmethyl]oxy}phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (892664-20-9)

Guidance literature:

4-chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -12 - -9 ℃; for 0.633333h;

2-isopropyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; diethyl ether; at -10 - 20 ℃; Product distribution / selectivity;

upstream raw materials:

2-isopropyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene

4-chloro-2-iodo phenol

Downstream raw materials:

ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate

6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylic acid