ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate

Base Information

Chemical Name:ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate
CAS No.:892663-09-1
Molecular Formula:C₂₂H₁₈Cl₂FNO₃
Molecular Weight:434.294
Hs Code.:

Synonyms:ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate

Suppliers and Price of ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate

There total 10 articles about ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 892663-03-5
ethyl 6-((5-chloro-2-hydroxyphenyl)methyl)-2-pyridinecarboxylate

: 71916-82-0
1-(bromomethyl)-4-chloro-2-fluorobenzene

: 892663-09-1
ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate

Guidance literature:: With potassium carbonate; In acetone; at 50 ℃;
DOI:10.1016/j.bmcl.2009.02.112

Reference yield: 51.0%

: 892664-14-1
(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)boronic acid

: 892664-08-3
ethyl 6-(chloromethyl)picolinate hydrochloride

: 892663-09-1
ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 90 ℃; for 2h; Large scale reaction;
DOI:10.1016/j.bmcl.2009.02.112

Reference yield:

: 892664-20-9
2-(5-chloro-2-{[4-chloro-2-fluorophenylmethyl]oxy}phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 49668-99-7
ethyl 6-chloromethylpyridine-2-carboxylate

: 892663-09-1
ethyl 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; DavePhos; In ethanol; toluene; at 86 ℃; for 3h; Inert atmosphere; Large scale reaction;
DOI:10.1021/op100072y