C₃₇H₄₈N₇O₂₀P

Base Information

• Chemical Name: C₃₇H₄₈N₇O₂₀P
• CAS No.: 208655-87-2
• Molecular Formula: C₃₇H₄₈N₇O₂₀P
• Molecular Weight: 941.797
• Mol file: 208655-87-2.mol

Synonyms:C₃₇H₄₈N₇O₂₀P

Chemical Property of C₃₇H₄₈N₇O₂₀P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₄₈N₇O₂₀P

There total 6 articles about C₃₇H₄₈N₇O₂₀P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[{(allyloxy)carbonyl}amino]acetic acid (90711-56-1) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + Fmoc-Thr-OH (73731-37-0) + 2-cyanoethyl-Nα-(9-fluorenylmethoxycarbonyl)tyrosin-4-yl-(2',3'-di-O-acetyluridin-5'-yl)phosphate (537677-37-5) → C37H48N7O20P (208655-87-2)

Guidance literature:

Multistep reaction; solid phase synthesis;

DOI:10.1016/S0040-4039(98)00558-9

Reference yield:

Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) → C37H48N7O20P (208655-87-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 90 percent / Cs₂CO₃ / dimethylformamide / 2 h

2: 70percent TFA / CH₂Cl₂ / 0.25 h

3: tetrazole / CH₂Cl₂; acetonitrile / 0.33 h

4: m-CPBA / CH₂Cl₂; acetonitrile / 0.33 h / 0 °C

5: HSnBu₃, AcOH / Pd(PPh₃)4 / tetrahydrofuran; CH₂Cl₂ / 1 h

6: solid phase synthesis

With 1H-tetrazole; tri-n-butyl-tin hydride; caesium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(98)00558-9

Reference yield:

(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-hydroxyphenyl)propanoate (143674-78-6) → C37H48N7O20P (208655-87-2)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrazole / CH₂Cl₂; acetonitrile / 0.33 h

2: m-CPBA / CH₂Cl₂; acetonitrile / 0.33 h / 0 °C

3: HSnBu₃, AcOH / Pd(PPh₃)4 / tetrahydrofuran; CH₂Cl₂ / 1 h

4: solid phase synthesis

With 1H-tetrazole; tri-n-butyl-tin hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(98)00558-9

upstream raw materials:

2-[{(allyloxy)carbonyl}amino]acetic acid

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Fmoc-Thr-OH

2-cyanoethyl-N^α-(9-fluorenylmethoxycarbonyl)tyrosin-4-yl-(2',3'-di-O-acetyluridin-5'-yl)phosphate