7-(5-(benzyloxy)pyridin-3-yl)-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one

Base Information

Chemical Name:7-(5-(benzyloxy)pyridin-3-yl)-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one
CAS No.:1610518-15-4
Molecular Formula:C₂₆H₂₈N₄O₄S₂
Molecular Weight:524.665
Hs Code.:

Synonyms:7-(5-(benzyloxy)pyridin-3-yl)-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one

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Chemical Property of 7-(5-(benzyloxy)pyridin-3-yl)-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one

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Technology Process of 7-(5-(benzyloxy)pyridin-3-yl)-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one

There total 8 articles about 7-(5-(benzyloxy)pyridin-3-yl)-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.8%

: 1190423-61-0
(5-(benzyloxy)pyridin-3-yl)boronic acid

: 1610520-84-7
(R)-7-bromo-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one

: 1610518-15-4
7-(5-(benzyloxy)pyridin-3-yl)-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 28948-60-9
2-bromothieno[3,2-c]pyridin-4(5H)-one

: 1610518-15-4
7-(5-(benzyloxy)pyridin-3-yl)-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - -60 °C / Inert atmosphere

1.2: 1 h / -60 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

3.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

3.2: 20 °C

4.1: acetic acid / methanol / 0.25 h / 20 °C

4.2: 1 h / 50 °C

5.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 0.33 h / 120 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; n-butyllithium; potassium carbonate; caesium carbonate; acetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; water;

Reference yield:

: 74115-13-2
5-bromopyridine-3-ol

: 1610518-15-4
7-(5-(benzyloxy)pyridin-3-yl)-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C

1.2: 2 h / 60 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.5 h / 110 °C / Microwave irradiation

3.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 0.33 h / 120 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; caesium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;