2-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-(4-chloro-phenyl)-ethyl ester

Base Information

• Chemical Name: 2-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-(4-chloro-phenyl)-ethyl ester
• CAS No.: 100287-72-7
• Molecular Formula: C₁₉H₁₆ClNO₅
• Molecular Weight: 373.793

Synonyms:2-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-(4-chloro-phenyl)-ethyl ester

Chemical Property of 2-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-(4-chloro-phenyl)-ethyl ester

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Technology Process of 2-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-(4-chloro-phenyl)-ethyl ester

There total 1 articles about 2-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-(4-chloro-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-Oxo-butyric acid 2-(4-chloro-phenyl)-ethyl ester (100303-68-2) + 2-nitro-benzaldehyde (552-89-6) → 2-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-(4-chloro-phenyl)-ethyl ester (100287-72-7)

Guidance literature:

With piperidine; acetic acid; In benzene; at 30 - 45 ℃; for 24h;

DOI:10.1248/cpb.35.3235

Reference yield: 76.0%

5-amino-3-cyclopentyl-1-methylpyrazole (92406-39-8) + 2-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-(4-chloro-phenyl)-ethyl ester (100287-72-7) → 3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-(4-chloro-phenyl)-ethyl ester; hydrochloride (100287-32-9)

Guidance literature:

In tert-butyl alcohol; at 80 ℃; for 24h;

DOI:10.1248/cpb.35.3235

Reference yield: 47.4%

1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine (118430-78-7) + 2-[1-(2-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-(4-chloro-phenyl)-ethyl ester (100287-72-7) → 1,6-Dimethyl-4-(2-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-(4-chloro-phenyl)-ethyl ester (118431-39-3)

Guidance literature:

In tert-butyl alcohol; at 80 ℃; for 24h;

DOI:10.1248/cpb.35.3235

upstream raw materials:

3-Oxo-butyric acid 2-(4-chloro-phenyl)-ethyl ester

2-nitro-benzaldehyde

Downstream raw materials:

3-Cyclopentyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-(4-chloro-phenyl)-ethyl ester; hydrochloride

1,6-Dimethyl-4-(2-nitro-phenyl)-3-thiophen-2-yl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-(4-chloro-phenyl)-ethyl ester

3-Cyclopentanecarbonyl-1,6-dimethyl-4-(2-nitro-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 2-(4-chloro-phenyl)-ethyl ester

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