L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-D-O-leucine-D-alanine benzyl ester

Base Information

Chemical Name:L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-D-O-leucine-D-alanine benzyl ester
CAS No.:1189526-11-1
Molecular Formula:C₇₀H₁₁₈N₆O₁₉Si
Molecular Weight:1375.82
Hs Code.:

Synonyms:L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-D-O-leucine-D-alanine benzyl ester

Suppliers and Price of L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-D-O-leucine-D-alanine benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-D-O-leucine-D-alanine benzyl ester

Chemical Property:

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Technology Process of L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-D-O-leucine-D-alanine benzyl ester

There total 12 articles about L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-D-O-leucine-D-alanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 1189526-11-1
L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-D-O-leucine-D-alanine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2: 4-methyl-benzoyl chloride; dmap; triethylamine / toluene / 20 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

4: 4-methyl-benzoyl chloride; dmap; triethylamine / toluene / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 4-methyl-benzoyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2020.127050

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 1189526-11-1
L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-D-O-leucine-D-alanine benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 50 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

4: 4-methyl-benzoyl chloride; dmap; triethylamine / toluene / 20 °C

5: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

6: 4-methyl-benzoyl chloride; dmap; triethylamine / toluene / 20 °C

With 1H-imidazole; dmap; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 4-methyl-benzoyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2020.127050

Reference yield:

: 1189526-10-0
L-OTBDMS-valine-L-valine benzyl ester

: 1189526-11-1
L-OTBDMS-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-L-valine-D-O-leucine-D-alanine-L-O-valine-D-O-leucine-D-alanine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

2: 4-methyl-benzoyl chloride; dmap; triethylamine / toluene / 20 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

4: 4-methyl-benzoyl chloride; dmap; triethylamine / toluene / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; 4-methyl-benzoyl chloride; triethylamine; In methanol; toluene;
DOI:10.1016/j.bmcl.2020.127050