methyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-3,4-dimethylthiophene-2-carboxylate

Base Information

Chemical Name:methyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-3,4-dimethylthiophene-2-carboxylate
CAS No.:1417798-20-9
Molecular Formula:C₂₁H₂₁NO₅S₂
Molecular Weight:431.533
Hs Code.:

Synonyms:methyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-3,4-dimethylthiophene-2-carboxylate

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Chemical Property of methyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-3,4-dimethylthiophene-2-carboxylate

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Technology Process of methyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-3,4-dimethylthiophene-2-carboxylate

There total 5 articles about methyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-3,4-dimethylthiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.2%

: 1417798-18-5
methyl 5-(3-bromo-4-methoxyphenyl)-3,4-dimethylthiophene-2-carboxylate

: 613660-87-0
4-sulfamoylphenylboronic acid

: 1417798-20-9
methyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-3,4-dimethylthiophene-2-carboxylate

Guidance literature:: methyl 5-(3-bromo-4-methoxyphenyl)-3,4-dimethylthiophene-2-carboxylate; 4-sulfamoylphenylboronic acid; With potassium carbonate; In ethanol; toluene; at 25 ℃; for 0.25h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 95 - 100 ℃; for 1h; Inert atmosphere; Sealed tube;

Reference yield:

: 33668-06-3
methyl 3,4-dimethylthiophene-2-carboxylate

: 1417798-20-9
methyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-3,4-dimethylthiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / dichloromethane / 3 h / 0 - 25 °C

2.1: potassium carbonate / toluene; ethanol / 0.25 h / 25 °C / Inert atmosphere

2.2: 2 h / 95 - 100 °C / Inert atmosphere; Sealed tube

3.1: acetic acid; bromine / 3 h / 25 °C

4.1: potassium carbonate / toluene; ethanol / 0.25 h / 25 °C / Inert atmosphere

4.2: 1 h / 95 - 100 °C / Inert atmosphere; Sealed tube

With bromine; potassium carbonate; acetic acid; In ethanol; dichloromethane; toluene;

Reference yield:

: 203195-42-0
methyl 3-bromo-4-methylthiophene-2-carboxylate

: 1417798-20-9
methyl 5-(6-methoxy-4'-sulfamoyl-[1,1'-biphenyl]-3-yl)-3,4-dimethylthiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.25 h / 25 °C / Inert atmosphere

1.2: 20 h / 95 - 100 °C / Inert atmosphere; Sealed tube

2.1: bromine / dichloromethane / 3 h / 0 - 25 °C

3.1: potassium carbonate / toluene; ethanol / 0.25 h / 25 °C / Inert atmosphere

3.2: 2 h / 95 - 100 °C / Inert atmosphere; Sealed tube

4.1: acetic acid; bromine / 3 h / 25 °C

5.1: potassium carbonate / toluene; ethanol / 0.25 h / 25 °C / Inert atmosphere

5.2: 1 h / 95 - 100 °C / Inert atmosphere; Sealed tube

With potassium phosphate; bromine; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; In ethanol; dichloromethane; toluene;