4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide

Base Information

Chemical Name:4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide
CAS No.:942195-86-0
Molecular Formula:C₁₈H₁₉N₃O₄S
Molecular Weight:373.433
Hs Code.:

Synonyms:4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide

Suppliers and Price of 4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 28 raw suppliers

Chemical Property of 4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide

There total 5 articles about 4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 942195-85-9
N,N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-4-[(phenylmethyl)oxyl]-1H-benzimidazole-6-carboxamide

: 942195-86-0
4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 30h; under 760.051 Torr;

Reference yield:

: 942195-80-4
N-[4-bromo-2-nitro-6-(benzyloxy)phenyl]acetamide

: 942195-86-0
4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: iron; acetic acid / 6 h / Heating / reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

2.2: 0.5 h / 0 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 32 h / 65 °C

3.2: 20 °C

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 30 h / 20 °C / 760.05 Torr

With hydrogen; iron; sodium hydride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 713530-47-3
2-(benzyloxy)-4-bromo-6-nitrobenzenamine

: 942195-86-0
4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 0.33 h / 70 °C

2.1: iron; acetic acid / 6 h / Heating / reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C

3.2: 0.5 h / 0 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 32 h / 65 °C

4.2: 20 °C

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 30 h / 20 °C / 760.05 Torr

With hydrogen; iron; sodium hydride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; palladium 10% on activated carbon; In tetrahydrofuran; N,N-dimethyl-formamide;