Technology Process of (R)-3-(4-methylphenyl)butanal
There total 23 articles about (R)-3-(4-methylphenyl)butanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -78 - 20 ℃;
DOI:10.1021/ol048790v
- Guidance literature:
-
With
diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; benzoic acid;
(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine;
In
chloroform;
at -20 ℃;
for 70h;
Title compound not separated from byproducts;
DOI:10.1016/j.tetlet.2006.08.063
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 84 percent / porcine pancreatic lipase / diethyl ether / Ambient temperature
2: Et3N, DMAP / CH2Cl2 / Ambient temperature
3: NaBH4 / dimethylsulfoxide / 60 °C
4: 88 percent / (i-Pr)2NEt / CH2Cl2 / Ambient temperature
5: 90 percent / 18-crown-6 / dimethylsulfoxide / 60 °C
6: 1.) DIBAL-H, 2.) 1 M aq. HCl / 1.) CH2Cl2, hexane, -78 deg C
With
hydrogenchloride; dmap; sodium tetrahydroborate; porcine pancreatic lipase; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine;
18-crown-6 ether;
In
diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/a702667f
