1-[4-(methylsulfonyl)phenyl]-2-(3-fluorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

Base Information

Chemical Name:1-[4-(methylsulfonyl)phenyl]-2-(3-fluorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole
CAS No.:1026235-80-2
Molecular Formula:C₁₇H₁₄F₄N₂O₃S
Molecular Weight:402.369
Hs Code.:

Synonyms:1-[4-(methylsulfonyl)phenyl]-2-(3-fluorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

Suppliers and Price of 1-[4-(methylsulfonyl)phenyl]-2-(3-fluorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[4-(methylsulfonyl)phenyl]-2-(3-fluorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[4-(methylsulfonyl)phenyl]-2-(3-fluorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

There total 4 articles about 1-[4-(methylsulfonyl)phenyl]-2-(3-fluorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 431-35-6
3-bromo-1,1,1-trifluoroacetone

: 3-Fluoro-N-(4-methanesulfonyl-phenyl)-benzamidine

: 1026235-80-2
1-[4-(methylsulfonyl)phenyl]-2-(3-fluorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

Guidance literature:: With sodium hydrogencarbonate; In isopropyl alcohol; at 75 - 80 ℃; for 20h;
DOI:10.1021/jm9700225

Reference yield:

: 403-54-3
m-Fluorobenzonitrile

: 1026235-80-2
1-[4-(methylsulfonyl)phenyl]-2-(3-fluorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

2: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 75 - 80 °C

With trimethylaluminum; sodium hydrogencarbonate; In isopropyl alcohol;
DOI:10.1021/jm9700225

Reference yield:

: 5470-49-5
4-methanesulfonylphenylamine

: 1026235-80-2
1-[4-(methylsulfonyl)phenyl]-2-(3-fluorophenyl)-4-trifluoromethyl-4-hydroxy-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

2: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 75 - 80 °C

With trimethylaluminum; sodium hydrogencarbonate; In isopropyl alcohol;
DOI:10.1021/jm9700225