4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenol

Base Information

• Chemical Name: 4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenol
• CAS No.: 154713-23-2
• Molecular Formula: C₁₈H₂₀N₄O
• Molecular Weight: 308.383
• Mol file: 154713-23-2.mol

Synonyms:4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenol

Chemical Property of 4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenol

There total 3 articles about 4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) → 4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenol (154713-23-2)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 90 °C

2: H₂ / Pd/C / ethanol / 20 °C

3: aq. Na₂S₂O₅ / ethanol / Heating

With sodium metabisulfite; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.06.069

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) → 4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenol (154713-23-2)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 90 °C

2: H₂ / Pd/C / ethanol / 20 °C

3: aq. Na₂S₂O₅ / ethanol / Heating

With sodium metabisulfite; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.06.069

Reference yield:

5-(4-methylpiperazine-1-yl)-2-nitroaniline (23491-48-7) → 4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenol (154713-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol / 20 °C

2: aq. Na₂S₂O₅ / ethanol / Heating

With sodium metabisulfite; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.bmcl.2004.06.069

upstream raw materials:

1-methyl-piperazine

5-chloro-2-nitroaniline

5-(4-methylpiperazine-1-yl)-2-nitroaniline

Downstream raw materials:

(2S)-N-{3-(4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenoxy)propoxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

(2S)-N-{4-(4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenoxy)butoxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

(2S)-N-{5-(4-[6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo[d]imidazol-2-yl]phenoxy)pentyloxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

(2S)-N-{3-(4-(6-(4-methylhexahydro-1-pyrazinyl)-1H-benzo [d]imidazol-2-yl)phenoxy) propoxy-5-methoxy-2-aminobenzoyl1}pyrrolidine2-carboxaldehyde diethyl thioacetal