5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(4-oxocyclohexyl)-3,4-dihydroquinolin-2(1H)-one

Base Information

Chemical Name:5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(4-oxocyclohexyl)-3,4-dihydroquinolin-2(1H)-one
CAS No.:1024500-43-3
Molecular Formula:C₂₇H₂₁Cl₃FNO₂
Molecular Weight:516.827
Hs Code.:

Synonyms:5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(4-oxocyclohexyl)-3,4-dihydroquinolin-2(1H)-one

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Chemical Property of 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(4-oxocyclohexyl)-3,4-dihydroquinolin-2(1H)-one

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Technology Process of 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(4-oxocyclohexyl)-3,4-dihydroquinolin-2(1H)-one

There total 1 articles about 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(4-oxocyclohexyl)-3,4-dihydroquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1024500-42-2
5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(1,4-dioxaspiro[4.5]dec-8-yl)-3,4-dihydroquinolin-2(1H)-one

: 1024500-43-3
5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(4-oxocyclohexyl)-3,4-dihydroquinolin-2(1H)-one

Guidance literature:: With Amberlyst 15; In acetone; at 20 ℃; for 5.5h;

Reference yield: 49.0%

: 1024500-43-3
5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(4-oxocyclohexyl)-3,4-dihydroquinolin-2(1H)-one

: 2748-02-9,13081-32-8
L-leucine tert-butyl ester hydrochloride

: 1024949-55-0
tert-butyl N-{4-[5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl]cyclohexyl}-L-leucinate

Guidance literature:: 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(4-oxocyclohexyl)-3,4-dihydroquinolin-2(1H)-one; L-leucine tert-butyl ester hydrochloride; With triethylamine; In 1,2-dichloro-ethane; for 0.333333h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 4h;

With water; sodium hydrogencarbonate; In dichloromethane; 1,2-dichloro-ethane;

Reference yield: 43.0%

: 1018674-12-8
cyclopentyl L-leucinate hydrochloride

: 1024500-43-3
5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(4-oxocyclohexyl)-3,4-dihydroquinolin-2(1H)-one

: 1024949-44-7
cyclopentyl N-{4-[5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl]cyclohexyl}-L-leucinate

Guidance literature:: cyclopentyl L-leucinate hydrochloride; 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-(4-oxocyclohexyl)-3,4-dihydroquinolin-2(1H)-one; With acetic acid; In 1,2-dichloro-ethane; for 0.0833333h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 18h;

With water; sodium hydrogencarbonate; In dichloromethane; 1,2-dichloro-ethane;