3-[2-(N-Boc-L-alanyl-L-alanyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Base Information

Chemical Name:3-[2-(N-Boc-L-alanyl-L-alanyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid
CAS No.:380306-46-7
Molecular Formula:C₂₉H₄₅N₃O₈
Molecular Weight:563.692
Hs Code.:

Synonyms:3-[2-(N-Boc-L-alanyl-L-alanyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

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Chemical Property of 3-[2-(N-Boc-L-alanyl-L-alanyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

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Technology Process of 3-[2-(N-Boc-L-alanyl-L-alanyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

There total 9 articles about 3-[2-(N-Boc-L-alanyl-L-alanyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-propionylamino]-3-methyl-butyric acid 2-(1,1-dimethyl-3-oxo-propyl)-3,5-dimethyl-phenyl ester

: 380306-46-7
3-[2-(N-Boc-L-alanyl-L-alanyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; In water; acetonitrile; at 0 - 20 ℃;
DOI:10.1002/1521-4184(200106)334:6<209::AID-ARDP209>3.0.CO;2-Y

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 380306-46-7
3-[2-(N-Boc-L-alanyl-L-alanyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 65 percent / 4-dimethylaminopyridine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

2: H₂ / Pd-C / ethanol / 2.5 h

3: 539 mg / CH₂Cl₂

4: H₂ / Pd-C / ethanol / 2.5 h

5: 200 mg / CH₂Cl₂

6: glac. HOAc / tetrahydrofuran; H₂O / 1 h / 20 °C

7: pyridinium chlorochromate / CH₂Cl₂

8: 90 mg / NaH₂PO₄; NaClO₂ / H₂O; acetonitrile / 0 - 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/1521-4184(200106)334:6<209::AID-ARDP209>3.0.CO;2-Y

Reference yield:

: 134098-64-9
2‐{3‐[(O‐tert‐butyldimethylsilyl)hydroxy]‐1,1‐dimethylpropyl}‐3,5‐dimethylphenol

: 380306-46-7
3-[2-(N-Boc-L-alanyl-L-alanyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 65 percent / 4-dimethylaminopyridine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

2: H₂ / Pd-C / ethanol / 2.5 h

3: 539 mg / CH₂Cl₂

4: H₂ / Pd-C / ethanol / 2.5 h

5: 200 mg / CH₂Cl₂

6: glac. HOAc / tetrahydrofuran; H₂O / 1 h / 20 °C

7: pyridinium chlorochromate / CH₂Cl₂

8: 90 mg / NaH₂PO₄; NaClO₂ / H₂O; acetonitrile / 0 - 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/1521-4184(200106)334:6<209::AID-ARDP209>3.0.CO;2-Y