3-acetyl-1-(benzyloxy)-4-hydroxy-5-<(p-benzyloxy)phenyl>-2(1H)-pyridinone

Base Information

Chemical Name:3-acetyl-1-(benzyloxy)-4-hydroxy-5-<(p-benzyloxy)phenyl>-2(1H)-pyridinone
CAS No.:81790-30-9
Molecular Formula:C₂₇H₂₃NO₅
Molecular Weight:441.483
Hs Code.:

Synonyms:3-acetyl-1-(benzyloxy)-4-hydroxy-5-<(p-benzyloxy)phenyl>-2(1H)-pyridinone

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Chemical Property of 3-acetyl-1-(benzyloxy)-4-hydroxy-5-<(p-benzyloxy)phenyl>-2(1H)-pyridinone

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Technology Process of 3-acetyl-1-(benzyloxy)-4-hydroxy-5-<(p-benzyloxy)phenyl>-2(1H)-pyridinone

There total 12 articles about 3-acetyl-1-(benzyloxy)-4-hydroxy-5-<(p-benzyloxy)phenyl>-2(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

: 81790-35-4
3-acetyl-1-(benzyloxy)-4-hydroxy-5-<(p-benzyloxy)phenyl>-5,6-dihydro-2(1H)-pyridinone

: 81790-30-9
3-acetyl-1-(benzyloxy)-4-hydroxy-5-<(p-benzyloxy)phenyl>-2(1H)-pyridinone

Guidance literature:: With chloranil; In ethylbenzene; for 16h; Heating;
DOI:10.1021/jo00136a005

Reference yield: 35.0%

: 81790-29-6
(E)-3-[Benzyloxy-(3-oxo-butyryl)-amino]-2-(4-benzyloxy-phenyl)-acrylic acid methyl ester

: 81790-26-3
methyl (E)-3-<(benzyloxy)amino>-2-propenoate

: 81790-30-9
3-acetyl-1-(benzyloxy)-4-hydroxy-5-<(p-benzyloxy)phenyl>-2(1H)-pyridinone

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; at 22 ℃; for 24h;
DOI:10.1021/jo00136a005

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 81790-30-9
3-acetyl-1-(benzyloxy)-4-hydroxy-5-<(p-benzyloxy)phenyl>-2(1H)-pyridinone

Guidance literature:: Multi-step reaction with 6 steps

1: BF₃*OEt₂ / 12 h / Ambient temperature

2: anhydrous potassium carbonate / butan-2-one / 24 h / Heating

3: 89 percent / N,N,N',N'-tetramethylethylenediamine / 12 h / 200 °C

4: 100 percent / camphorsulfonic acid (CSA) / benzene / 12 h / Heating

5: 1.) sec-BuLi / 1.) THF, -78 deg C

6: 35 percent / NaH / dimethylsulfoxide / 24 h / 22 °C

With N,N,N,N,-tetramethylethylenediamine; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; sec.-butyllithium; sodium hydride; potassium carbonate; In dimethyl sulfoxide; butanone; benzene;
DOI:10.1021/jo00136a005