2R,3R-2,3-epoxybutyric acid-p-methoxyphenylamide

Base Information

• Chemical Name: 2R,3R-2,3-epoxybutyric acid-p-methoxyphenylamide
• CAS No.: 84939-32-2
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229

Synonyms:2R,3R-2,3-epoxybutyric acid-p-methoxyphenylamide

Chemical Property of 2R,3R-2,3-epoxybutyric acid-p-methoxyphenylamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 2R,3R-2,3-epoxybutyric acid-p-methoxyphenylamide

There total 4 articles about 2R,3R-2,3-epoxybutyric acid-p-methoxyphenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S,3R)-2-Bromo-3-hydroxy-N-(4-methoxy-phenyl)-butyramide (84939-28-6) → 2R,3R-2,3-epoxybutyric acid-p-methoxyphenylamide (84939-32-2)

Guidance literature:

With sodium hydroxide; triethylbenzylammonium iodide; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4039(00)81597-X

Reference yield:

4-methoxy-aniline (104-94-9) → 2R,3R-2,3-epoxybutyric acid-p-methoxyphenylamide (84939-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

2: 100 percent / 50percent aq NaOH / benzyltriethylammonium iodide / CH₂Cl₂ / 0.5 h / Ambient temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; triethylbenzylammonium iodide; In dichloromethane;

DOI:10.1016/S0040-4039(00)81597-X

Reference yield:

C16H19NO5 → 2R,3R-2,3-epoxybutyric acid-p-methoxyphenylamide (84939-32-2)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at -40 - 20 ℃;

DOI:10.1016/j.mencom.2018.03.005

upstream raw materials:

(2S,3R)-2-Bromo-3-hydroxy-N-(4-methoxy-phenyl)-butyramide

(2R,3R)-2,3-epoxybutanoic acid

4-methoxy-aniline

Downstream raw materials:

(2R,3R)-3-Methyl-oxirane-2-carboxylic acid (4-methoxy-phenyl)-phenylsulfanylmethyl-amide

(3S,4S,1'R) N-p-methoxyphenyl-3-(1'-hydroxyethyl)-4-benzoylazetidin-2-one

1-N-(p-Methoxyphenyl)-(3S,4R)-3-[1(R)-hydroxyethyl]-4-phenylsulfonylazetidin-2-one

(3S,4S)-3-((R)-1-Hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-phenylsulfanyl-azetidin-2-one

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