(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionic acid benzyl ester

Base Information

Chemical Name:(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionic acid benzyl ester
CAS No.:180714-69-6
Molecular Formula:C₂₅H₃₉N₃O₆
Molecular Weight:477.601
Hs Code.:

Synonyms:(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionic acid benzyl ester

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Chemical Property of (R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionic acid benzyl ester

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Technology Process of (R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionic acid benzyl ester

There total 2 articles about (R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 65365-33-5
Boc-Leu-Sar-OH

: (R)-2-Methylamino-propionic acid benzyl ester; hydrochloride

: 180714-69-6
(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionic acid benzyl ester

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; Ambient temperature;
DOI:10.1002/hlca.19960790303

Reference yield:

: 147864-45-7
Boc-Leu-Sar-OCH₂Ph

: 180714-69-6
(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / H₂ / methanol

2: 84 percent / N,N-diisopropylethylamine, bis(2-oxooxazolidin-3-yl)phosphinic chloride / CH₂Cl₂ / Ambient temperature

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1002/hlca.19960790303

Reference yield:

: 180714-69-6
(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionic acid benzyl ester

: 180714-73-2
[(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionylamino]-acetic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / H₂ / Pd/C / methanol

2: 53 percent / N,N-diisopropylethylamine, bis(2-oxooxazolidin-3-yl)phosphinic chloride / CH₂Cl₂ / 48 h / -15 - -5 °C

3: 97 percent / H₂ / Pd/C / methanol

4: 8.0 g / pyridine / 0 - 25 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In pyridine; methanol; dichloromethane;
DOI:10.1002/hlca.19960790303