<4-amino-2,2-difluoro-3-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate

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Chemical Name:<4-amino-2,2-difluoro-3-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate
CAS No.:109064-97-3
Molecular Formula:C₂HF₃O₂*C₂₃H₃₆F₂N₄O₄
Molecular Weight:584.584
Hs Code.:

Synonyms:<4-amino-2,2-difluoro-3-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate

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Chemical Property of <4-amino-2,2-difluoro-3-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate

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Technology Process of <4-amino-2,2-difluoro-3-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate

There total 6 articles about <4-amino-2,2-difluoro-3-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 109064-95-1
<4(S)--2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide

: 76-05-1
trifluoroacetic acid

: 109064-97-3
<4(S)-amino-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate

Guidance literature:: In dichloromethane; for 0.166667h; Ambient temperature;
DOI:10.1021/jm00392a016

Reference yield:

: 33900-15-1
(2S)-N-[(1S)-2-amino-1-benzyl-2-oxoethyl]-2-[(tert-butoxycarbonyl)amino]-4-methylpentanamide

: 109064-97-3
<4(S)-amino-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 89.8 percent / HCl / ethyl acetate / 0.75 h / Ambient temperature

2: HOBt, N-methylmorpholine (NMM), DCC / dimethylformamide

3: 90 percent / CH₂Cl₂ / 0.17 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00392a016

Reference yield:

: 58521-45-2
tert-butoxycarbonyl-L-leucinal

: 109064-97-3
<4(S)-amino-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-leucyl-L-phenylalaninamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 44.9 percent / Zn / tetrahydrofuran / 0.25 h / Heating

2: 80.9 percent / 1 M aq. NaOH / tetrahydrofuran / 2 h

3: HOBt, N-methylmorpholine (NMM), DCC / dimethylformamide

4: 90 percent / CH₂Cl₂ / 0.17 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00392a016