Technology Process of 4-chloro-2-(4-fluorophenyl)-5-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine
There total 6 articles about 4-chloro-2-(4-fluorophenyl)-5-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-chloro-2-(4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]-pyridine;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 - 5 ℃;
for 0.5h;
(2-trimethylethylsilylethoxy)methyl chloride;
DOI:10.1021/jm3016014
- Guidance literature:
-
Multi-step reaction with 5 steps
1: copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.17 h / 80 °C / Sealed tube
2: potassium tert-butylate; 1-methyl-pyrrolidin-2-one / 12 h / 20 - 120 °C / Inert atmosphere
3: 3-chloro-benzenecarboperoxoic acid / acetone / 12 h / 5 - 20 °C
4: trichlorophosphate / 3 h / 85 °C
5: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 5 °C
With
1-methyl-pyrrolidin-2-one; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; sodium hydride; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1021/jm3016014
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: silver trifluoroacetate / 1,2-dichloro-ethane / 7 h / Reflux
1.2: 12 h / 20 °C / Heating
2.1: copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.17 h / 80 °C / Sealed tube
3.1: potassium tert-butylate; 1-methyl-pyrrolidin-2-one / 12 h / 20 - 120 °C / Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / acetone / 12 h / 5 - 20 °C
5.1: trichlorophosphate / 3 h / 85 °C
6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 5 °C
With
1-methyl-pyrrolidin-2-one; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; silver trifluoroacetate; sodium hydride; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate;
In
tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1021/jm3016014