(R)-2-N-(benzyloxycarbonyl)serinol monovalerate

Base Information

• Chemical Name: (R)-2-N-(benzyloxycarbonyl)serinol monovalerate
• CAS No.: 114838-34-5
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.362
• Mol file: 114838-34-5.mol

Synonyms:(R)-2-N-(benzyloxycarbonyl)serinol monovalerate

Chemical Property of (R)-2-N-(benzyloxycarbonyl)serinol monovalerate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-N-(benzyloxycarbonyl)serinol monovalerate

There total 2 articles about (R)-2-N-(benzyloxycarbonyl)serinol monovalerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

vinyl valerate (5873-43-8) + N-Benzyloxycarbonyl-1,3-dihydroxy-2-aminopropane (71811-26-2) → (R)-2-N-(benzyloxycarbonyl)serinol monovalerate (114838-34-5)

Guidance literature:

In tetrahydrofuran; at 28 ℃; for 11h; porcine pancreatic lipase;

DOI:10.1021/jo00248a046

Reference yield:

valeric acid (109-52-4) → (R)-2-N-(benzyloxycarbonyl)serinol monovalerate (114838-34-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / mercuric acetate / 100percent sulfuric acid / 6 h / Heating

2: 77 percent / porcine pancreas / tetrahydrofuran / 11 h / 28 °C

With mercury(II) diacetate; porcine pancreas; sulfuric acid; In tetrahydrofuran;

DOI:10.1021/ja00229a041

Reference yield:

(R)-2-N-(benzyloxycarbonyl)serinol monovalerate (114838-34-5) → benzyl (R)-1-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-ylcarbamate

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium tosylate

2: LiBH₄ / diethyl ether

With lithium borohydride; pyridinium p-toluenesulfonate; In diethyl ether;

DOI:10.1021/ja00229a041

upstream raw materials:

vinyl valerate

N-Benzyloxycarbonyl-1,3-dihydroxy-2-aminopropane

valeric acid