1-Bromo-3-bromomethyl-2-fluorobenzene

Base Information

• Chemical Name: 1-Bromo-3-bromomethyl-2-fluorobenzene
• CAS No.: 149947-16-0
• Molecular Formula: C7H5 Br2 F
• Molecular Weight: 267.923
• Hs Code.: 2903999090
• Mol file: 149947-16-0.mol

Synonyms:1-Bromo-3-bromomethyl-2-fluorobenzene

Chemical Property of 1-Bromo-3-bromomethyl-2-fluorobenzene

Chemical Property:

• Vapor Pressure: 0.0271mmHg at 25°C
• Refractive Index: 1.583
• Boiling Point: 254.8°Cat760mmHg
• Flash Point: 107.9°C
• PSA: 0.00000
• Density: 1.923g/cm³
• LogP: 3.48310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-2-fluorobenzylbromide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used to obtain the target inhibitors. A new quasi-one-dimensional molecular solid based on Ni (mnt) 2 anion: Crystal structure and spin-gap transition 4-Bromo-2-fluorobenzyl bromide acts as stasrting material.

Technology Process of 1-Bromo-3-bromomethyl-2-fluorobenzene

There total 5 articles about 1-Bromo-3-bromomethyl-2-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-bromo-2-fluorotoluene (59907-12-9) → 1-bromo-3-(bromomethyl)-2-fluorobenzene (149947-16-0)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 20 ℃; for 20.5h; Reflux;

DOI:10.1021/acs.jmedchem.7b00259

Reference yield:

1-bromo-2-fluoro-3-(hydroxymethyl)benzene (261723-32-4) → 1-bromo-3-(bromomethyl)-2-fluorobenzene (149947-16-0)

Guidance literature:

With carbon tetrabromide; triphenylphosphine;

DOI:10.1016/S0960-894X(00)00416-9

Reference yield:

o-fluorobromobenzene (1072-85-1) → 1-bromo-3-(bromomethyl)-2-fluorobenzene (149947-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: n-BuLi

2: LiAlH₄

3: CBr₄; PPh₃

With lithium aluminium tetrahydride; n-butyllithium; carbon tetrabromide; triphenylphosphine; 1: Metallation / 1: Carboxylation / 2: Reduction / 3: Bromination;

DOI:10.1016/S0960-894X(00)00416-9

upstream raw materials:

1-bromo-2-fluoro-3-(hydroxymethyl)benzene

o-fluorobromobenzene

3-bromo-2-fluorobenzoic acid

3-bromo-2-fluorotoluene

Downstream raw materials:

(3-{4-[1-(3-bromo-2-fluoro-benzyloxy)-ethyl]-2-methoxy-5-nitro-phenoxy}-propyl)-carbamic acid tert-butyl ester

3-bromo-2-fluorobenzaldehyde

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND AND USE THEREOF". Paragraph 0356. . Retrieved 2019/02/15.
• 2、 -. "Substituted 1-benzylcycloalkylcarboxylic acids and the use thereof". Page/Page column 19-20. . Retrieved 2012/07/14.