261723-32-4

Basic information

• Product Name: (3-bromo-2-fluorophenyl)methanol
• Synonyms: (3-bromo-2-fluorophenyl)methanol;3-Bromo-2-fluorobenzyl alcohol 98%;3-BroMo-2-Fluoro-BenzeneMethanol;1-Bromo-2-fluoro-3-(hydroxymethyl)benzene;3-Bromo-2-fluoro-benzyl alcohal
• CAS NO: 261723-32-4
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 205.03
• Mol File: 261723-32-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 36.0 to 40.0 °C
• Boiling Point: 263.232 °C at 760 mmHg
• Flash Point: 112.999 °C
• Appearance: /
• Density: 1.658 g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: 0-10°C
• PKA: 13.80±0.10(Predicted)
• CAS DataBase Reference: (3-bromo-2-fluorophenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-bromo-2-fluorophenyl)methanol(261723-32-4)
• EPA Substance Registry System: (3-bromo-2-fluorophenyl)methanol(261723-32-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 261723-32-4(Hazardous Substances Data)

Usage

General Description

(3-bromo-2-fluorophenyl)methanol is a chemical compound with the molecular formula C7H6BrFO. It is a white solid that is soluble in organic solvents and is commonly used as a building block in the synthesis of various organic compounds. The compound is often employed as a reagent in organic chemistry reactions, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. Additionally, the compound has potential applications in pharmaceuticals, agrochemicals, and materials science due to its versatile chemical reactivity and potential for creating new chemical structures. As a result, (3-bromo-2-fluorophenyl)methanol is a valuable chemical tool in the development of new compounds for a variety of industrial and research purposes.

InChI:InChI=1/C7H6BrFO/c8-6-3-1-2-5(4-10)7(6)9/h1-3,10H,4H2

Upstream product

• 206551-41-9 2-fluoro-3-bromobenzoic acid methyl ester 
• 149947-15-9 3-bromo-2-fluorobenzaldehyde 
• 1072-85-1 o-fluorobromobenzene 
• 161957-56-8 3-bromo-2-fluorobenzoic acid 

Downstream Products

• 88430-50-6 beraprost 314d 

Relevant articles and documents

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

PD-1/PD-L1 INHIBITORS

Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); R1a and R1b may be the same or different and each independently represents a C1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X1 represents a hydroxyl group or an aminocarbonyl group; Z1 represents a single bond or the like; and R2 represents an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group or the like.)