261723-32-4

Basic information

• Product Name: (3-bromo-2-fluorophenyl)methanol
• Synonyms: (3-bromo-2-fluorophenyl)methanol;3-Bromo-2-fluorobenzyl alcohol 98%;3-BroMo-2-Fluoro-BenzeneMethanol;1-Bromo-2-fluoro-3-(hydroxymethyl)benzene;3-Bromo-2-fluoro-benzyl alcohal
• CAS NO: 261723-32-4
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 205.03
• Mol File: 261723-32-4.mol

Chemical Properties

• Melting Point: 36.0 to 40.0 °C
• Boiling Point: 263.232 °C at 760 mmHg
• Flash Point: 112.999 °C
• Appearance: /
• Density: 1.658 g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: 0-10°C
• PKA: 13.80±0.10(Predicted)
• CAS DataBase Reference: (3-bromo-2-fluorophenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-bromo-2-fluorophenyl)methanol(261723-32-4)
• EPA Substance Registry System: (3-bromo-2-fluorophenyl)methanol(261723-32-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 261723-32-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(3-bromo-2-fluorophenyl)methanol is used as a building block for the synthesis of various organic compounds, leveraging its ability to participate in the formation of carbon-carbon and carbon-heteroatom bonds, which is crucial for creating complex molecular structures.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, (3-bromo-2-fluorophenyl)methanol is used as a reagent in the development of new drugs, capitalizing on its versatile chemical properties to create innovative pharmaceutical agents with potential therapeutic applications.
Used in Agrochemical Industry:
(3-bromo-2-fluorophenyl)methanol is employed as a key intermediate in the synthesis of agrochemicals, contributing to the development of new pesticides or other agricultural chemicals that can enhance crop protection and yield.
Used in Materials Science:
Within the realm of materials science, (3-bromo-2-fluorophenyl)methanol is utilized for the creation of new materials with specific properties, such as those with altered electronic, optical, or mechanical characteristics, by incorporating its unique structure into the material's composition.
Overall, (3-bromo-2-fluorophenyl)methanol is a valuable chemical tool in the advancement of new compounds for a multitude of industrial and research applications, underpinning its significance in contemporary chemical innovation.

InChI:InChI=1/C7H6BrFO/c8-6-3-1-2-5(4-10)7(6)9/h1-3,10H,4H2

Upstream product

• 206551-41-9 2-fluoro-3-bromobenzoic acid methyl ester 
• 149947-15-9 3-bromo-2-fluorobenzaldehyde 
• 1072-85-1 o-fluorobromobenzene 
• 161957-56-8 3-bromo-2-fluorobenzoic acid 

Downstream Products

• 149947-16-0 1-bromo-3-(bromomethyl)-2-fluorobenzene 
• 88430-50-6 beraprost 314d 
• 1698908-91-6 2-[3-(difluoromethyl)-2-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1204333-52-7 1-bromo-3-(difluoromethyl)-2-fluorobenzene 
• 149947-15-9 3-bromo-2-fluorobenzaldehyde 
• 786652-60-6 1-bromo-3-(chloromethyl)-2-fluorobenzene 

Relevant articles and documents

PYRIDINE COMPOUND SUBSTITUTED WITH AZOLE

The present invention provides a compound represented by formula [I] shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme. (in formula [I] above, the structure represented by formula [II] below: represents any of the structures represented by formula group [III] below: R1, R2, R3, and R4 independently represent a hydrogen atom, a fluorine atom, methyl, or the like, R5 represents any of the structures represented by formula group [IV]:

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

PD-1/PD-L1 INHIBITORS

Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

Enantioselective Total Synthesis of Beraprost Using Organocatalyst

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Substituted 1-benzylcycloalkylcarboxylic acids and the use thereof

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8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); R1a and R1b may be the same or different and each independently represents a C1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X1 represents a hydroxyl group or an aminocarbonyl group; Z1 represents a single bond or the like; and R2 represents an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group or the like.)

POLYSUBSTITUTED DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO[1,2-a]PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF

Compounds of formula (I): wherein R1, R2, R3, R4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.

OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF

The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases

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PHENOXY ACETIC ACID DERIVATIVES

The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.