(S)-2-(2-Fluoro-phenyl)-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-4,5-dihydro-oxazole

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Chemical Name:(S)-2-(2-Fluoro-phenyl)-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-4,5-dihydro-oxazole
CAS No.:179117-34-1
Molecular Formula:C₁₇H₂₂FNO₃
Molecular Weight:307.365
Hs Code.:

Synonyms:(S)-2-(2-Fluoro-phenyl)-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-4,5-dihydro-oxazole

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Chemical Property of (S)-2-(2-Fluoro-phenyl)-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-4,5-dihydro-oxazole

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Technology Process of (S)-2-(2-Fluoro-phenyl)-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-4,5-dihydro-oxazole

There total 4 articles about (S)-2-(2-Fluoro-phenyl)-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 179117-12-5
(4'S)-2-[2'-(2''-fluorophenyl)-4',5'-dihydrooxazol-4'-yl]-propan-2-ol

: 179117-34-1
(S)-2-(2-Fluoro-phenyl)-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-4,5-dihydro-oxazole

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1016/0040-4020(96)00267-0

Reference yield:

: 393-52-2
2-Fluorobenzoyl chloride

: 179117-34-1
(S)-2-(2-Fluoro-phenyl)-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / NaHCO₃ / H₂O / 1.5 h

2: 65 percent / tetrahydrofuran; diethyl ether / Ambient temperature

3: 84 percent / Et₃N, p-TsCl / CH₂Cl₂ / 24 h / Heating

4: 90 percent / p-TsOH / CH₂Cl₂

With sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/0040-4020(96)00267-0

Reference yield:

: 179117-11-4
(1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide

: 179117-34-1
(S)-2-(2-Fluoro-phenyl)-4-[1-methyl-1-(tetrahydro-pyran-2-yloxy)-ethyl]-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / Et₃N, p-TsCl / CH₂Cl₂ / 24 h / Heating

2: 90 percent / p-TsOH / CH₂Cl₂

With toluene-4-sulfonic acid; triethylamine; p-toluenesulfonyl chloride; In dichloromethane;
DOI:10.1016/0040-4020(96)00267-0