(1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide

Base Information

Chemical Name:(1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide
CAS No.:179117-11-4
Molecular Formula:C₁₂H₁₆FNO₃
Molecular Weight:241.262
Hs Code.:

Synonyms:(1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide

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Chemical Property of (1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide

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Technology Process of (1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide

There total 4 articles about (1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 75-16-1
methylmagnesium bromide

: 179117-06-7
(2S)-2-(2'-fluorobenzoylamino)-3-hydroxypropionic acid methyl ester

: 179117-11-4
(1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide

Guidance literature:: methylmagnesium bromide; (2S)-2-(2'-fluorobenzoylamino)-3-hydroxypropionic acid methyl ester; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 18h;

With ammonium chloride; In tetrahydrofuran; diethyl ether; at 0 ℃; Saturated solution;
DOI:10.1016/j.tet.2011.02.021

Reference yield: 70.0%

: 75-16-1
methylmagnesium bromide

: 179117-06-7
(2S)-2-(2'-fluorobenzoylamino)-3-hydroxypropionic acid methyl ester

: 1301708-22-4
2-fluoro-N-(2'-hydroxymethyl-2'-oxopropyl)-benzamide

: 179117-11-4
(1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide

Guidance literature:: methylmagnesium bromide; (2S)-2-(2'-fluorobenzoylamino)-3-hydroxypropionic acid methyl ester; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 19.17h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at 0 ℃;
DOI:10.1002/chem.201003314