4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one

Base Information

• Chemical Name: 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one
• CAS No.: 1414976-16-1
• Molecular Formula: C₁₈H₁₃N₃O₂
• Molecular Weight: 303.32
• Mol file: 1414976-16-1.mol

Synonyms:4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one

Chemical Property of 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one

There total 3 articles about 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

7-methyl-1H-indazole-5-carbaldehyde (635712-40-2) + Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) → 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one (1414976-16-1)

Guidance literature:

7-methyl-1H-indazole-5-carbaldehyde; With potassium acetate; acetic anhydride; at 25 ℃; for 1h; Large scale;

Hippuric Acid; at 60 ℃; for 6.5h; Large scale;

DOI:10.1021/op3003097

Reference yield:

4-bromo-2,6-dimethylphenylamine (24596-19-8) → 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one (1414976-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium acetate / toluene / 0.5 h / Large scale

1.2: 6.5 h / 40 - 45 °C / Large scale

2.1: n-butyllithium / tetrahydrofuran; hexane; cyclohexane / 0.33 h / -60 °C / Large scale

2.2: 2.25 h / -50 - 5 °C / Large scale

3.1: potassium acetate; acetic anhydride / 1 h / 25 °C / Large scale

3.2: 6.5 h / 60 °C / Large scale

With n-butyllithium; potassium acetate; acetic anhydride; In tetrahydrofuran; hexane; cyclohexane; toluene;

DOI:10.1021/op3003097

Reference yield:

5-bromo-7-methyl-1H-indazole (156454-43-2) → 4-((7-methyl-1H-indazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one (1414976-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane; cyclohexane / 0.33 h / -60 °C / Large scale

1.2: 2.25 h / -50 - 5 °C / Large scale

2.1: potassium acetate; acetic anhydride / 1 h / 25 °C / Large scale

2.2: 6.5 h / 60 °C / Large scale

With n-butyllithium; potassium acetate; acetic anhydride; In tetrahydrofuran; hexane; cyclohexane;

DOI:10.1021/op3003097

upstream raw materials:

4-bromo-2,6-dimethylphenylamine

5-bromo-7-methyl-1H-indazole

7-methyl-1H-indazole-5-carbaldehyde

Hippuric Acid

Downstream raw materials:

methyl 2-benzamido-3-(7-methyl-1H-indazol-5-yl)-acrylate