Technology Process of Ac-T(4-(SCH2CH=CHCH2OH)-Phe)PN-NH2
There total 4 articles about Ac-T(4-(SCH2CH=CHCH2OH)-Phe)PN-NH2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Hoveyda-Grubbs catalyst second generation; magnesium(II) chloride hexahydrate;
In
tert-butyl alcohol;
at 20 ℃;
for 2h;
pH=8;
aq. phosphate buffer;
Inert atmosphere;
DOI:10.1021/ol202947f
- Guidance literature:
-
Multi-step reaction with 4 steps
1: copper(l) iodide; 1,10-Phenanthroline; N-ethyl-N,N-diisopropylamine / tert-Amyl alcohol / 11 h / 90 °C
2: DL-dithiothreitol / 1 h / 20 °C / pH 7.2 / aq. phosphate buffer
3: 1 h / 20 °C / pH 8 / aq. phosphate buffer
4: Hoveyda-Grubbs catalyst second generation; magnesium(II) chloride hexahydrate / tert-butyl alcohol / 2 h / 20 °C / pH 8 / aq. phosphate buffer; Inert atmosphere
With
copper(l) iodide; Hoveyda-Grubbs catalyst second generation; 1,10-Phenanthroline; magnesium(II) chloride hexahydrate; DL-dithiothreitol; N-ethyl-N,N-diisopropylamine;
In
tert-Amyl alcohol; tert-butyl alcohol;
DOI:10.1021/ol202947f
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1 h / 20 °C / pH 8 / aq. phosphate buffer
2: Hoveyda-Grubbs catalyst second generation; magnesium(II) chloride hexahydrate / tert-butyl alcohol / 2 h / 20 °C / pH 8 / aq. phosphate buffer; Inert atmosphere
With
Hoveyda-Grubbs catalyst second generation; magnesium(II) chloride hexahydrate;
In
tert-butyl alcohol;
DOI:10.1021/ol202947f
