(2S,3R)-2-benzyl-3-(methoxymethoxymethyl)-1-(4-methylphenylsulfonyl)aziridine

Base Information

Chemical Name:(2S,3R)-2-benzyl-3-(methoxymethoxymethyl)-1-(4-methylphenylsulfonyl)aziridine
CAS No.:496941-78-7
Molecular Formula:C₁₉H₂₃NO₄S
Molecular Weight:361.462
Hs Code.:

Synonyms:(2S,3R)-2-benzyl-3-(methoxymethoxymethyl)-1-(4-methylphenylsulfonyl)aziridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-2-benzyl-3-(methoxymethoxymethyl)-1-(4-methylphenylsulfonyl)aziridine

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Technology Process of (2S,3R)-2-benzyl-3-(methoxymethoxymethyl)-1-(4-methylphenylsulfonyl)aziridine

There total 4 articles about (2S,3R)-2-benzyl-3-(methoxymethoxymethyl)-1-(4-methylphenylsulfonyl)aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 98-59-9
p-toluenesulfonyl chloride

: 496941-89-0
(2S,3R)-2-benzyl-3-(methoxymethoxymethyl)aziridine

: 496941-78-7
(2S,3R)-2-benzyl-3-(methoxymethoxymethyl)-1-(4-methylphenylsulfonyl)aziridine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 25 ℃; for 12h;
DOI:10.1016/S0040-4020(02)00729-9

Reference yield:

: 42238-15-3,22910-59-4,49676-93-9
(2E)-4-phenylbut-2-en-1-ol

: 496941-78-7
(2S,3R)-2-benzyl-3-(methoxymethoxymethyl)-1-(4-methylphenylsulfonyl)aziridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: D-(-)-diethyl tartrate; Ti(O-i-Pr)4; t-BuOOH / CH₂Cl₂; decane / 48 h / -23 °C

2.1: 89 percent / ethyldiisopropylamine / CH₂Cl₂ / 14 h / 20 °C

3.1: NaN₃; NH₄Cl / 2-methoxy-ethanol; H₂O / 6 h / 80 °C

3.2: 1.48 g / PPh₃ / toluene / 24 h / Heating

4.1: 46 percent / N,N-dimethylpyridin-4-amine; triethylamine / CH₂Cl₂ / 12 h / 25 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; sodium azide; diethyl (2S,3S)-tartrate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In decane; dichloromethane; 2-methoxy-ethanol; water;
DOI:10.1016/S0040-4020(02)00729-9

Reference yield:

: 78571-81-0,81096-89-1,85531-71-1,99883-80-4,128575-26-8,116949-62-3
(R,R)-3-(phenylmethyl)oxiranemethanol

: 496941-78-7
(2S,3R)-2-benzyl-3-(methoxymethoxymethyl)-1-(4-methylphenylsulfonyl)aziridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / ethyldiisopropylamine / CH₂Cl₂ / 14 h / 20 °C

2.1: NaN₃; NH₄Cl / 2-methoxy-ethanol; H₂O / 6 h / 80 °C

2.2: 1.48 g / PPh₃ / toluene / 24 h / Heating

3.1: 46 percent / N,N-dimethylpyridin-4-amine; triethylamine / CH₂Cl₂ / 12 h / 25 °C

With dmap; sodium azide; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; 2-methoxy-ethanol; water;
DOI:10.1016/S0040-4020(02)00729-9