(Z)-isopropyl 3-(3-(3-(cyclobutylamino)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Base Information

Chemical Name:(Z)-isopropyl 3-(3-(3-(cyclobutylamino)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
CAS No.:1333152-16-1
Molecular Formula:C₁₉H₂₁F₃N₄O₂
Molecular Weight:394.397
Hs Code.:

Synonyms:(Z)-isopropyl 3-(3-(3-(cyclobutylamino)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

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Chemical Property of (Z)-isopropyl 3-(3-(3-(cyclobutylamino)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

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Technology Process of (Z)-isopropyl 3-(3-(3-(cyclobutylamino)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

There total 6 articles about (Z)-isopropyl 3-(3-(3-(cyclobutylamino)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1333154-05-4
N-cyclobutyl-3-(1H-1,2,4-triazol-3-yl)-5-(trifluoromethyl)aniline

: 1333154-26-9
(Z)-isopropyl 3-iodoacrylate

: 1333152-16-1
(Z)-isopropyl 3-(3-(3-(cyclobutylamino)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

: 1421924-03-9
(E)-isopropyl 3-(3-(3-(cyclobutylamino)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: N-cyclobutyl-3-(1H-1,2,4-triazol-3-yl)-5-(trifluoromethyl)aniline; With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; for 0.5h;

(Z)-isopropyl 3-iodoacrylate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Time;

Reference yield:

: 96088-62-9
isopropyl propiolate

: 1333154-05-4
N-cyclobutyl-3-(1H-1,2,4-triazol-3-yl)-5-(trifluoromethyl)aniline

: 1333152-16-1
(Z)-isopropyl 3-(3-(3-(cyclobutylamino)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 149793-69-1
3-fluoro-5-trifluoromethyl-benzonitrile

: 1333152-16-1
(Z)-isopropyl 3-(3-(3-(cyclobutylamino)-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 100 °C

2.1: sodium hydrogen sulfide; magnesium chloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: hydrazine hydrate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 90 °C

4.1: triethylamine / dichloromethane / 0.5 h / 20 °C

With sodium hydrogen sulfide; potassium carbonate; hydrazine hydrate; triethylamine; magnesium chloride; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;