1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-5-yl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

Base Information

Chemical Name:1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-5-yl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea
CAS No.:1355346-68-7
Molecular Formula:C₂₉H₃₁N₇O₄
Molecular Weight:541.61
Hs Code.:

Synonyms:1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-5-yl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

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Chemical Property of 1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-5-yl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

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Technology Process of 1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-5-yl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

There total 9 articles about 1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-5-yl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1355347-40-8
2-tert-butyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazole-5-carboxylic acid

: 347161-75-5
3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline

: 1355346-68-7
1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-5-yl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

Guidance literature:: 2-tert-butyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazole-5-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; at 60 ℃; for 1h;

3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline; In 1,4-dioxane; at 100 ℃; for 10h;

Reference yield:

: 2-chloro p-aminophenol hydrochloride

: 1355346-68-7
1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-5-yl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C

1.2: 100 °C

2.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 1 h / 60 °C

2.2: 10 h / 100 °C

With diphenyl phosphoryl azide; sodium hydride; triethylamine; In 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 630-18-2
tert-butyl isocyanide

: 1355346-68-7
1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-5-yl]-3-[4-(6,7-dimethoxyquinolin-4-yloxy)phenyl]urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / 1,4-dioxane / 26 h / 20 °C

2.1: triethylamine / acetonitrile / 3 h / 80 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; trichloroisocyanuric acid / acetonitrile / 0.75 h / 0 °C

4.1: acetic acid; trifluoroacetic acid; N-iodo-succinimide / 30 h / 20 °C

5.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dichloro-ethane / 4 h / 90 °C / Inert atmosphere

6.1: potassium hydroxide / tetrahydrofuran; water / 7 h / 60 °C

7.1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 1 h / 60 °C

7.2: 10 h / 100 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; trichloroisocyanuric acid; diphenyl phosphoryl azide; potassium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane; acetonitrile;