ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2,4-dimethyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

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Chemical Name:ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2,4-dimethyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate
CAS No.:1420070-45-6
Molecular Formula:C₂₇H₃₀F₃N₃O₃
Molecular Weight:501.549
Hs Code.:

Synonyms:ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2,4-dimethyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

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Chemical Property of ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2,4-dimethyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

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Technology Process of ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2,4-dimethyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

There total 12 articles about ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2,4-dimethyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13061-96-6
dihydroxy-methyl-borane

: 1420070-44-5
ethyl {4-chloro-3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2-methyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

: 1420070-45-6
ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2,4-dimethyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In dichloromethane; monoethylene glycol diethyl ether; at 120 ℃; for 4h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 102684-91-3
2-bromo-5-(trifluoromethyl)benzaldehyde

: 1420070-45-6
ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2,4-dimethyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium cyanoborohydride; acetic acid / methanol; tetrahydrofuran / 20 °C

2: triethylamine / dichloromethane / 20 °C

3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 100 °C / Schlenk technique; Sealed tube; Inert atmosphere

4: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.58 h / 120 °C / Inert atmosphere; Microwave irradiation

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,2-dimethoxyethane / 4 h / 120 °C / Inert atmosphere; Microwave irradiation

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1175526-32-5
N-[2-bromo-5-(trifluoromethyl)benzyl]ethanamine

: 1420070-45-6
ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-2,4-dimethyl-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 20 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 100 °C / Schlenk technique; Sealed tube; Inert atmosphere

3: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.58 h / 120 °C / Inert atmosphere; Microwave irradiation

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,2-dimethoxyethane / 4 h / 120 °C / Inert atmosphere; Microwave irradiation

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; triethylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;