Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester

Base Information

Chemical Name:Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester
CAS No.:266694-67-1
Molecular Formula:C₂₂H₃₂O₄S
Molecular Weight:392.56
Hs Code.:

Synonyms:Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester

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Chemical Property of Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester

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Technology Process of Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester

There total 2 articles about Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 98-88-4
benzoyl chloride

: 111998-90-4
(R)-3-((2R,4aR,7R,8aR)-4,4,7-Trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butane-1,3-diol

: 266694-67-1
Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 0.5h;
DOI:10.1002/jccs.200000006

Reference yield:

: 3-Hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyric acid tert-butyl ester

: 266694-67-1
Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / LiAlH₄ / diethyl ether / 2 h / Heating

2: 99 percent / Et₃N / CH₂Cl₂ / 0.5 h

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane; 1: Reduction / 2: Acylation;
DOI:10.1002/jccs.200000006

Reference yield:

: 266694-67-1
Benzoic acid (R)-3-hydroxy-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-butyl ester

: (1R)-2-hydroxy-2-methyl-4-benzoyloxybutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NCS; AgNO₃; NaHCO₃ / acetonitrile; H₂O / 0.42 h

2: NaClO₂; KH₂PO₄; 3-methyl-2-butene / acetonitrile; H₂O / 0.67 h / 20 °C

With sodium chlorite; potassium dihydrogenphosphate; N-chloro-succinimide; 2-methyl-but-2-ene; sodium hydrogencarbonate; silver nitrate; In water; acetonitrile; 1: oxidative cleavage / 2: Oxidation;
DOI:10.1002/jccs.200000006